Publication: Serum trace metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand
Issued Date
1994-10-01
Resource Type
ISSN
14355922
09441174
09441174
Other identifier(s)
2-s2.0-0028124239
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Gastroenterology. Vol.29, No.5 (1994), 610-615
Suggested Citation
C. Pramoolsinsap, N. Promvanit, S. Komindr, P. Lerdverasirikul, S. Srianujata Serum trace metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand. Journal of Gastroenterology. Vol.29, No.5 (1994), 610-615. doi:10.1007/BF02365444 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9633
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Title
Serum trace metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand
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Abstract
This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (± 13) [mean (± SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twenty-five patients had chronic persistent hepatitis, 32 chronic active hepatitis, 21 post-necrotic cirrhosis, and 20 hepatocellular carcinoma. Determination of fasting serum trace metal levels (zinc, copper, calcium, magnesium, and phosphorus) was performed after the patients had been on a 2-day diet containing 10-12 mg zinc/day. Compared to healthy volunteers (n=30), serum zinc levels were significantly decreased in patients with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma (P≤0.0001), and copper levels were significantly elevated only in patients with hepatocellular carcinoma (P < 0.0001). The overall serum levels of calcium, magnesium, and phosphorus were within normal ranges, and levels of calcium and magnesium correlated with serum zinc (P=0.01-0.03). Serum zinc levels correlated with bilirubin, albumin, and cholesterol (P=0.0004≤0.0001), but not with daily urinary zinc excretion. Serum copper levels correlated with alkaline phosphatase and gamma-glutamyltransferase (P=0.008-0.0001). These results suggested that changes in liver cell pathology compounded by functional impairment may alter the metabolism of trace metals, in particular, zinc and copper. The possible relationship of these changes to the pathogenesis of chronic liver disease is discussed. © 1994 Springer-Verlag.