Publication: Polymorphisms of serotonin 4 receptor gene associated with schizophrenia in Thai ethnic
Issued Date
2019-07-01
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ISSN
01252208
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2-s2.0-85070331913
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.102, No.7 (2019), 29-34
Suggested Citation
W. Turakitwanakan, B. Panichareon, W. Sukhumsirichart Polymorphisms of serotonin 4 receptor gene associated with schizophrenia in Thai ethnic. Journal of the Medical Association of Thailand. Vol.102, No.7 (2019), 29-34. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51558
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Title
Polymorphisms of serotonin 4 receptor gene associated with schizophrenia in Thai ethnic
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Abstract
© JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019. Background: Serotonin 5-HT4 receptor (HTR4) is involved in learning and memory process. The location of this gene is in schizophrenia-susceptible loci. Objective: The present study aimed to investigate the variation in HTR4 gene in association with schizophrenia in Thai population. Materials and Methods: A total of 75 schizophrenia patients and 170 normal controls volunteered in this study. DNAs were extracted from whole blood. The purified DNAs were amplified and genotyped by PCR using 3’-locked nucleic acid (LNA) modified SNP primers and by high resolution melting (HRM) analysis. The differences in genotype distribution between patients and controls were assessed by Chi-square test of the SPSS software version 11.5. Results: All studied SNPs were in Hardy-Weinberg equilibrium. Two SNPs, rs2277051 and rs2277049, showed significant association with schizophrenia (p = 0.001, and p = 0.015, respectively). The genotype C of rs2277051 and G of rs2277049 existed in schizophrenia more than in control. Conclusion: The authors found two SNPs in intronic region of serotonin 5-HT4 receptor gene, rs2277051 and rs2277049, that related to the susceptibility for schizophrenia in Thai population.