Publication: Recent applications of microchip electrophoresis to biomedical analysis
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Issued Date
2015-03-20
Resource Type
ISSN
1873264X
07317085
07317085
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2-s2.0-84939253849
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Pharmaceutical and Biomedical Analysis. Vol.113, (2015), 72-96
Suggested Citation
Nantana Nuchtavorn, Worapot Suntornsuk, Susan M. Lunte, Leena Suntornsuk Recent applications of microchip electrophoresis to biomedical analysis. Journal of Pharmaceutical and Biomedical Analysis. Vol.113, (2015), 72-96. doi:10.1016/j.jpba.2015.03.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35487
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Title
Recent applications of microchip electrophoresis to biomedical analysis
Abstract
© 2015 Elsevier B.V.. Many separation methods have been developed for biomedical analysis, including chromatographic (. e.g. high performance liquid chromatography (HPLC) and gas chromatography (GC)) and electrophoretic methods (. e.g. gel electrophoresis and capillary electrophoresis (CE)). Among these techniques, CE provides advantages in terms of high separation efficiency, simplicity, low sample and solvent volume consumption, short analysis time and applicability to a wide range of biomedically important substances. Microchip electrophoresis (ME) is a miniaturized platform of CE and is now considered as a simpler and more convenient alternative, which has demonstrated potential in analytical chemistry. High-throughput, cost-effective and portable analysis systems can be developed using ME. The current review describes different separation modes and detectors that have been employed in ME to analyze various classes of biomedical analytes (. e.g. pharmaceuticals and related substances, nucleic acids, amino acids, peptides, proteins, antibodies and antigens, carbohydrates, cells, cell components and lysates). Recent applications (during 2010-2014) in these areas are presented in tables and some significant findings are highlighted.