Publication: Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
Issued Date
2018-12-01
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ISSN
20411723
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2-s2.0-85047179219
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Communications. Vol.9, No.1 (2018)
Suggested Citation
Evelien M. Bunnik, Kate B. Cook, Nelle Varoquaux, Gayani Batugedara, Jacques Prudhomme, Anthony Cort, Lirong Shi, Chiara Andolina, Leila S. Ross, Declan Brady, David A. Fidock, Francois Nosten, Rita Tewari, Photini Sinnis, Ferhat Ay, Jean Philippe Vert, William Stafford Noble, Karine G. Le Roch Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages. Nature Communications. Vol.9, No.1 (2018). doi:10.1038/s41467-018-04295-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44992
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Title
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
Other Contributor(s)
Département de Mathématiques et Applications
Institut Curie
Mines ParisTech
Columbia University in the City of New York
University of California, Riverside
Columbia University Medical Center
University of Oxford
University of California, Berkeley
University of Texas Health Science Center at San Antonio
University of Washington, Seattle
University of Nottingham
La Jolla Institute for Allergy and Immunology
Mahidol University
Johns Hopkins Bloomberg School of Public Health
Inserm
Berkeley Global Science Institute
Institut Curie
Mines ParisTech
Columbia University in the City of New York
University of California, Riverside
Columbia University Medical Center
University of Oxford
University of California, Berkeley
University of Texas Health Science Center at San Antonio
University of Washington, Seattle
University of Nottingham
La Jolla Institute for Allergy and Immunology
Mahidol University
Johns Hopkins Bloomberg School of Public Health
Inserm
Berkeley Global Science Institute
Abstract
© 2018 The Author(s). The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression. Furthermore, we observe reorganization of subtelomeric heterochromatin around genes involved in host cell remodeling. Depletion of heterochromatin protein 1 (PfHP1) resulted in loss of interactions between virulence genes, confirming that PfHP1 is essential for maintenance of the repressive center. Our results suggest that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycle.