Publication:
Balanced salt solution versus normal saline solution as initial fluid resuscitation in pediatric septic shock: A randomized, double-blind controlled trial

dc.contributor.authorNattachai Anantasiten_US
dc.contributor.authorSriwanna Thasanthiahen_US
dc.contributor.authorRojjanee Lertbunrianen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.date.accessioned2020-10-05T06:38:12Z
dc.date.available2020-10-05T06:38:12Z
dc.date.issued2020-01-01en_US
dc.description.abstract© 2020, The Indonesian Foundation of Critical Care Medicine. All rights reserved. Objective: Initial fluid resuscitation is mandato-ry in treatment of septic shock. Current sepsis guidelines do not have the recommendation for either balanced salt or normal saline solution for initial fluid resuscitation. The objective of this study was to determine the impact of balanced salt solution (BS) versus normal saline solution (NS) in pediatric septic shock as initial fluid resuscitation. Design: A double-blind randomized controlled trial study. Setting: A single tertiary care center in Bang-kok, Thailand. Patients and participants: Children aged 1 month to 18 years who were diagnosed with septic shock. We excluded patients who received fluid resuscitation in the 24 hours prior to septic shock, end-stage disease, and refusal of in-formed consent. Interventions: Patients were randomly assigned into 2 groups after being diagnosed with septic shock and required fluid resuscitation (NS or BS). Measurements and results: Demographic data, vasoactive-inotropic scores, and outcomes were evaluated. The primary outcome was incidence of hyperchloremic metabolic acidosis. Sixty-one septic shock children were enrolled into this study (NS=31 patients, and BS=30 patients). Baseline characteristics between two groups were not different. The incidence of hyperchlor-emic metabolic acidosis was 17 (54.8%) and 10 (33.3%) in NS and BS groups, respectively (p=0.091). The hospital mortality and preva-lence of acute kidney injury were not different between groups. Conclusion: In pediatric septic shock, the initial fluid resuscitation with balanced salt solution and normal saline was associated with similar clinical outcomes. However, normal saline solution had a trend toward more frequent hyper-chloremic metabolic acidosis in children with septic shock when compared to balanced salt solution.en_US
dc.identifier.citationCritical Care and Shock. Vol.23, No.4 (2020), 158-168en_US
dc.identifier.issn14107767en_US
dc.identifier.other2-s2.0-85089623958en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/59267
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089623958&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleBalanced salt solution versus normal saline solution as initial fluid resuscitation in pediatric septic shock: A randomized, double-blind controlled trialen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089623958&origin=inwarden_US

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