Publication: How to Contain Artemisinin- and Multidrug-Resistant Falciparum Malaria
Issued Date
2017-05-01
Resource Type
ISSN
14715007
14714922
14714922
Other identifier(s)
2-s2.0-85011628834
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Trends in Parasitology. Vol.33, No.5 (2017), 353-363
Suggested Citation
Arjen M. Dondorp, Frank M. Smithuis, Charley Woodrow, Lorenz von Seidlein How to Contain Artemisinin- and Multidrug-Resistant Falciparum Malaria. Trends in Parasitology. Vol.33, No.5 (2017), 353-363. doi:10.1016/j.pt.2017.01.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42833
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Title
How to Contain Artemisinin- and Multidrug-Resistant Falciparum Malaria
Abstract
© 2017 The Author(s) In the Greater Mekong subregion (GMS), artemisinin resistance is increasingly compounded by partner drug resistance, causing high failure rates of artemisinin combination therapies in some areas. For its containment, an accelerated elimination strategy will be needed. This includes high-quality implementation of conventional malaria control measures: early case management with quality artemisinin combination therapies (avoiding artesunate monotherapies) and single gametocytocidal low dose of primaquine, vector control and surveillance. Village health workers (VHWs) play a key role in the provision of community-based services which have to reach even the most remote populations. Additional, more aggressive, approaches will be important to accelerate malaria elimination, which could include mass drug administrations, potentially in combination with ivermectin and vaccination, mass screening and treatment with novel diagnostics, reactive case detection, and other measures.