Publication: Factors associated with cerebral malaria
Issued Date
2013-01-01
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ISSN
01251562
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2-s2.0-84893635257
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.44, No.6 (2013), 941-949
Suggested Citation
Bipin Adhikari, Noppadon Tangpukdee, Srivicha Krudsood, Polrat Wilairatana Factors associated with cerebral malaria. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.44, No.6 (2013), 941-949. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32586
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Title
Factors associated with cerebral malaria
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Abstract
We conducted a retrospective unmatched case-control study using the medical records of patients admitted to the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand to investigate factors associated with cerebral malaria. The records of 137 patients with severe Plasmodium falciparum without cerebral malaria and 35 patients with cerebral malaria hospitalized during 1997-2005 were reviewed and compared. Ten factors associated with cerebral malaria were identified: pulmonary edema [odds ratio (OR)= 13.8; 95% confidence interval (CI): 1.3-143.2], splenomegaly (OR=3.7; 95% CI: 1.3-44.7), fever (OR=3.3; 95% CI: 1.7-14.3), day 1 malarial density ≤249,999/μl (OR=1.6; 95% CI: 1.1-14.6), day 2 malarial density ≤249,999/μl (OR=3.4; 95% CI: 1.3-35.1), dyspnea (OR=1.4; 95% CI: 1.2-12.1), hepatomegaly (OR=1.8; 95% CI: 0.2-12.1), being a referred patient (OR=1.3; 95% CI: 1.0-2.2), a higher systolic blood pressure (OR=1.2; 95% CI: 1.0-2.1) and a higher body mass index (OR=1.6; 95% CI: 1.0-2.6). Pulmonary edema was the strongest factor associated with cerebral malaria in our study. Clinicians who treat patients with severe Plasmodium falciparum malaria should be aware these factors are associated with cerebral malaria.