Publication: Molecular self assembly of mixed comb-like dextran surfactant polymers for SPR virus detection
Issued Date
2014-11-04
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ISSN
01448617
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2-s2.0-84903584117
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Mahidol University
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SCOPUS
Bibliographic Citation
Carbohydrate Polymers. Vol.112, (2014), 440-447
Suggested Citation
Katanchalee Mai-Ngam, Wansika Kiatpathomchai, Narong Arunrut, Jitlada Sansatsadeekul Molecular self assembly of mixed comb-like dextran surfactant polymers for SPR virus detection. Carbohydrate Polymers. Vol.112, (2014), 440-447. doi:10.1016/j.carbpol.2014.06.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33609
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Title
Molecular self assembly of mixed comb-like dextran surfactant polymers for SPR virus detection
Abstract
The synthesis of two comb-like dextran surfactant polymers, that are different in their dextran molecular weight (MW) distribution and the presence of carboxylic groups, and their characterization are reported. A bimodal carboxylic dextran surfactant polymer consists of poly(vinyl amine) (PVAm) backbone with carboxyl higher MW dextran, non-functionalized lower MW dextran and hydrophobic hexyl branches; while a monomodal dextran surfactant polymer is PVAm grafted with non-functionalized lower MW dextran and hexyl branches. Layer formation of non-covalently attached dextran chains with bimodal MW distributions on a surface plasmon resonance (SPR) chip was investigated from the perspective of mixed physisorption of the bimodal and monomodal surfactant polymers. Separation distances between the carboxylic longer dextran side chains within the bimodal surfactant polymer and between the whole bimodal surfactant molecules on the chip surface could be well-controlled. SPR analysis of shrimp yellow head virus using our mixed surfactant chips showed dependence on synergetic adjustment of these separation distances. © 2014 Elsevier Ltd.