Publication: Silk sericin loaded alginate nanoparticles: Preparation and anti-inflammatory efficacy
Issued Date
2015-09-01
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ISSN
18790003
01418130
01418130
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2-s2.0-84937872961
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Biological Macromolecules. Vol.80, (2015), 636-643
Suggested Citation
Thitikan Khampieng, Pornanong Aramwit, Pitt Supaphol Silk sericin loaded alginate nanoparticles: Preparation and anti-inflammatory efficacy. International Journal of Biological Macromolecules. Vol.80, (2015), 636-643. doi:10.1016/j.ijbiomac.2015.07.018 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35386
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Title
Silk sericin loaded alginate nanoparticles: Preparation and anti-inflammatory efficacy
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Abstract
© 2015 Elsevier B.V. In this study, silk sericin loaded alginate nanoparticles were prepared by the emulsification method followed by internal crosslinking. The effects of various silk sericin loading concentration on particle size, shape, thermal properties, and release characteristics were investigated. The initial silk sericin loadings of 20, 40, and 80% w/w to polymer were incorporated into these alginate nanoparticles. SEM images showed a spherical shape and small particles of about 71.30-89.50. nm. TGA analysis showed that thermal stability slightly increased with increasing silk sericin loadings. FTIR analysis suggested interactions between alginate and silk sericin in the nanoparticles. The release study was performed in acetate buffer at normal skin conditions (pH 5.5; 32. °C). The release profiles of silk sericin exhibited initial rapid release, consequently with sustained release. These silk sericin loaded alginate nanoparticles were further incorporated into topical hydrogel and their anti-inflammatory properties were studied using carrageenan-induced paw edema assay. The current study confirms the hypothesis that the application of silk sericin loaded alginate nanoparticle gel can inhibit inflammation induced by carrageenan.