Publication: Isolation and characterisation of crocosin, an antibacterial compound from crocodile (Crocodylus siamensis) plasma
Issued Date
2010-06-01
Resource Type
ISSN
17400929
13443941
13443941
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2-s2.0-77953883209
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Mahidol University
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SCOPUS
Bibliographic Citation
Animal Science Journal. Vol.81, No.3 (2010), 393-401
Suggested Citation
Sutthidech Preecharram, Pornpimol Jearranaiprepame, Sakda Daduang, Yosapong Temsiripong, Theerasak Somdee, Tamo Fukamizo, Jisnuson Svasti, Tomohiro Araki, Sompong Thammasirirak Isolation and characterisation of crocosin, an antibacterial compound from crocodile (Crocodylus siamensis) plasma. Animal Science Journal. Vol.81, No.3 (2010), 393-401. doi:10.1111/j.1740-0929.2010.00752.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28498
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Title
Isolation and characterisation of crocosin, an antibacterial compound from crocodile (Crocodylus siamensis) plasma
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Abstract
An antibacterial compound from crocodile blood was partially purified and functionally characterised. The freshwater crocodile (Crocodylus siamensis) plasma with antibacterial activity was partially purified by using a centrifugal concentrator and reverse phase high powered liquid chromatography, and designated as crocosin. Crocosin exhibits antibacterial activity toward Salmonella typhi and Staphylococcus aureus. Crocosin is thermostable and resistant to pronase digestion. The structure of crocosin analyzed by mass spectrometry contains repeating units of 94 and 136 m/z. Scanning electron microscopy indicates that crocosin probably penetrates progressively into cytoplasm space, perturbing and damaging bacterial membranes. Crocosin may provide an early defense mechanism toward bacterial infection in freshwater. © 2010 The Authors. Journal compilation © 2010 Japanese Society of Animal Science.