Publication: Comparison of the immunogenicity of a monovalent influenza A/H1N1 2009 vaccine between healthy individuals, patients with chronic renal failure, and immunocompromised populations
Issued Date
2014-01-01
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ISSN
18732623
00411345
00411345
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2-s2.0-84896479890
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Mahidol University
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SCOPUS
Bibliographic Citation
Transplantation Proceedings. Vol.46, No.2 (2014), 328-331
Suggested Citation
S. P. Watcharananan, A. Thakkinstian, C. Srichunrasmee, W. Chuntratita, V. Sumethkul Comparison of the immunogenicity of a monovalent influenza A/H1N1 2009 vaccine between healthy individuals, patients with chronic renal failure, and immunocompromised populations. Transplantation Proceedings. Vol.46, No.2 (2014), 328-331. doi:10.1016/j.transproceed.2013.11.063 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34505
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Title
Comparison of the immunogenicity of a monovalent influenza A/H1N1 2009 vaccine between healthy individuals, patients with chronic renal failure, and immunocompromised populations
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Abstract
Background Data on the immunogenicity (IG) of the influenza vaccine among patients at high risk of influenza-related complication are limited. Methods We studied the antibody titer following a single dose of monovalent 2009 influenza A (H1N1) vaccine between groups of adult patients who were healthy, those with chronic renal failure (CRF), kidney transplant (KT) recipients, and human immunodeficiency virus (HIV)-infected patients. The IG (primary endpoints) was accessed at 4 weeks after vaccination. The secondary endpoint was safety of the vaccine. Results A total of 293 patients were studied. Patients' mean age was 41(standard deviation [SD], 13.3) years old. At baseline, mean age (P <.001), history of vaccination in a prior year (P <.001), and geometric mean titers (GMT; P <.001) significantly differed between each groups and the majority (70%) of participants had the hemagglutination inhibition titer <1:10. The IG of the vaccine was highest in the healthy group (71.4 %). The response rate among CRF, KT, and HIV groups was 42.4% (risk ratios [RR], 0.72; 95% confidence interval [CI], 0.5-1.02), 31.9% (RR, 0.51; 95% CI, 0.34-0.76), and 29.7% (RR, 0.42; 95% CI, 0.3-0.6), respectively. The vaccine was well-tolerated in all studied groups. Thirty (10.2%) patients experienced at least 1 adverse reaction but systemic reaction was uncommon (3.4%). Conclusions A single dose of monovalent 2009 influenza A (H1N1) vaccine result in poor IG among high-risk populations, including CRF, KT and HIV patients. © 2014 by Elsevier Inc. All rights reserved.