Publication: Risk factors between analgesic use and chronic nephropathy in Thailand
Issued Date
1996-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0030154668
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.27, No.2 (1996), 350-355
Suggested Citation
Surasak Kantachuvesiri, Sming Kaojarern, Dwip Kitayaporn, Sophon Phanichphant, Vasant Sumethkul, Winai Wananukul, Cholathip Pongskul, Wiwat Arkaravichien, Suchat Jankriengkri, Tawee Chanchairujira Risk factors between analgesic use and chronic nephropathy in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.27, No.2 (1996), 350-355. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17743
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Risk factors between analgesic use and chronic nephropathy in Thailand
Other Contributor(s)
Abstract
Analgesic abuse is common in Thailand. Heavy use of analgesic may also increase risk of chronic nephropathy. However, the extent of this risk remains unclear. We carried out a case-control study in three referral hospitals. A total of 84 patients with newly diagnosed of chronic tubulointerstitial nephritis were enrolled as cases. Two control groups were randomly selected, 192 from hospitalized patients who had no renal disease and serum creatinine below 3.2 mg/dl and 166 from relatives of friends visiting the hospitals. Both cases and controls were interviewed by a standardized pre-coded questionnaire to obtain histories of analgesic use before diagnosis of renal disease. On multiple logistic regression analysis, patients whose estimated lifetime use of acetaminophen of 1,000 g or more had an increased risk of chronic nephropathy compared with non-users, the odds ratio (OR) was 5.9 (95% confidence interval (Cl) 1.3-25.6, hospital controls) and OR = 5.8 (95% Cl 1.04-31.9, visitor controls). Also, uses of aspirin showed a similar relationship. Patients who used aspirin 1,000 g or more per lifetime had higher risk of chronic nephropathy when compared to non-users, the odds ratio were 7.1 (95% Cl 2.0-25.8, hospital controls) and 20.4 (95% Cl 2.4-174.2) for visitor controls. These data indicate that analgesic abuse increased risk of chronic nephropathy in Thailand.