Publication: An evaluation of hepatitis B virus diagnostic methods and responses to antiretroviral therapy among HIV-infected women in Thailand
Issued Date
2013-09-01
Resource Type
ISSN
23259582
23259574
23259574
Other identifier(s)
2-s2.0-84884699180
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the International Association of Providers of AIDS Care. Vol.12, No.5 (2013), 349-353
Suggested Citation
Philip James Peters, Janet M. McNicholl, Boonyos Raengsakulrach, Punneeporn Wasinrapee, Famui Mueanpai, Winai Ratanasuwan, Poj Intalapaporn, Jan Drobeniuc, Sumathi Ramachandran, Hong Thai, Guo Liang Xia, Saleem Kamili, Yury Khudyakov, Paul J. Weidle, Chong Gee Teo, Michelle S. McConnell An evaluation of hepatitis B virus diagnostic methods and responses to antiretroviral therapy among HIV-infected women in Thailand. Journal of the International Association of Providers of AIDS Care. Vol.12, No.5 (2013), 349-353. doi:10.1177/2325957413488201 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31879
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Title
An evaluation of hepatitis B virus diagnostic methods and responses to antiretroviral therapy among HIV-infected women in Thailand
Abstract
Coinfection with HIV and hepatitis B virus (HBV) is common in resource-limited settings but is frequently not diagnosed. The authors retrospectively tested specimens for HBV in HIV-infected Thai women who had participated in an antiretroviral therapy (ART) clinical study. A substantial proportion (27 of 211; 13%) of HIV-infected women were HBV coinfected. Among HIV/HBV-coinfected women, the authors observed similar rates of antiretroviral-associated liver toxicity (despite nevirapine [NVP] use) and CD4 count reconstitution as observed in HIV-monoinfected women. Hepatitis B surface antigen (HBsAg) screening detected the majority (81%) of HBV coinfections, including all 5 HBV-coinfected women who did not suppress HBV despite 48 weeks of lamivudine (3TC)-containing ART and could be used to tailor ART for patients diagnosed with HBV coinfection in accordance with World Health Organization guidelines. Although HBsAg screening did not diagnose 5 occult HBV coinfections, these women achieved HBV suppression on 3TC-containing ART, suggesting that not detecting occult HBV coinfection would have limited clinical impact. © The Author(s) 2013.