Publication: Single bolus intravenous ephedrine attenuates reduction of core body temperature in patients undergoing spinal anesthesia for arthroscopic knee and ankle surgery
Issued Date
2020-01-01
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ISSN
01252208
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2-s2.0-85079428441
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.103, No.2 (2020), 134-141
Suggested Citation
T. Pravitharangul, C. Karnjanarachata, P. Areeruk, S. Thananuwong, R. Komonhirun Single bolus intravenous ephedrine attenuates reduction of core body temperature in patients undergoing spinal anesthesia for arthroscopic knee and ankle surgery. Journal of the Medical Association of Thailand. Vol.103, No.2 (2020), 134-141. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/53808
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Title
Single bolus intravenous ephedrine attenuates reduction of core body temperature in patients undergoing spinal anesthesia for arthroscopic knee and ankle surgery
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Abstract
© JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND Objective: To determine the efficacy of a single bolus ephedrine on body temperature reduction attenuation during arthroscopic knee and ankle surgery under spinal anesthesia. Materials and Methods: The present study was a single-center prospective randomized clinical trial. Patients undergoing arthroscopic ankle or knee surgery were randomized to receive a single intravenous bolus dose of placebo (normal saline) or ephedrine 9 milligrams (mg) just after a subarachnoid injection for spinal anesthesia. Tympanic membrane temperature and blood pressure were recorded at time points. Two-way repeated-measures ANOVAs was performed to analyze the difference of temperature at time points compared with before performing spinal block as primary outcome. Results: Forty patients were randomized, and 34 patients were included in outcome analysis (control n=18 and ephedrine n=16). Patients in the ephedrine group demonstrated better body temperature preservation. The earliest significant effect could be seen 7.5 minutes after the spinal block (control group –0.32±0.39℃ and ephedrine group –0.24±0.5℃, p=0.007). The ephedrine effect on blood pressure was subtle. Conclusion: For patients undergoing knee or ankle arthroscopic surgery, a single bolus 9 mg of ephedrine given intravenously just after the subarachnoid injection for spinal anesthesia can preserve core temperature.