Publication: Structural basis for selectivity and toxicity of ribosomal antibiotics
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Issued Date
2001-05-15
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ISSN
1469221X
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2-s2.0-0035032997
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Mahidol University
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SCOPUS
Bibliographic Citation
EMBO Reports. Vol.2, No.4 (2001), 318-323
Suggested Citation
Erik C. Böttger, Burkhard Springer, Therdsak Prammananan, Yishak Kidan, Peter Sander Structural basis for selectivity and toxicity of ribosomal antibiotics. EMBO Reports. Vol.2, No.4 (2001), 318-323. doi:10.1093/embo-reports/kve062 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26464
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Title
Structural basis for selectivity and toxicity of ribosomal antibiotics
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Abstract
Ribosomal antibiotics must discriminate between bacterial and eukaryotic ribosomes to various extents. Despite major differences in bacterial and eukaryotic ribosome structure, a single nucleotide or amino acid determines the selectivity of drugs affecting protein synthesis. Analysis of resistance mutations in bacteria allows the prediction of whether cytoplasmic or mitochondrial ribosomes in eukaryotic cells will be sensitive to the drug. This has important implications for drug specificity and toxicity. Together with recent data on the structure of ribosomal subunits these data provide the basis for development of new ribosomal antibiotics by rationale drug design.