Publication: Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries
Issued Date
2015-09-03
Resource Type
ISSN
17474094
17474086
17474086
Other identifier(s)
2-s2.0-84941260990
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Hematology. Vol.8, No.5 (2015), 627-645
Suggested Citation
Miguela A. Caniza, Carla Odio, Sheena Mukkada, Miriam Gonzalez, Francesco Ceppi, Sujittra Chaisavaneeyakorn, Nopporn Apiwattanakul, Scott C. Howard, Valentino Conter, Miguel Bonilla Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries. Expert Review of Hematology. Vol.8, No.5 (2015), 627-645. doi:10.1586/17474086.2015.1071186 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36335
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Title
Infectious complications in children with acute lymphoblastic leukemia treated in low-middle-income countries
Abstract
© 2015 © Informa UK, Ltd. Infections are the most important cause of morbidity and mortality in children treated for acute lymphoblastic leukemia (ALL). The rates of infection-Associated mortality are up to 10-Times higher in low-and middle-income countries (LMIC) than in high-income countries. The prevention, early recognition and management of infectious complications is especially challenging in LMIC because of disease and poverty-related factors, as well as the shortage of trained personnel, supplies, diagnostic tools and adequate organizational infrastructure. Children in LMIC with ALL, who are frequently underweight, are at increased risk of community-Acquired pathogens, nosocomial multidrug-resistant pathogens and opportunistic microorganisms. This review summarizes the challenges of managing the major categories of infections in children receiving treatment for ALL and provides updated practical recommendations for preventing and managing these infections in LMIC.