Publication:
Ovarian cancer and body size: Individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies

Issued Date

2012-04-01

Resource Type

Article

ISSN

15491676
15491277

DOI

10.1371/journal.pmed.1001200

Other identifier(s)

2-s2.0-84860157091

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

PLoS Medicine. Vol.9, No.4 (2012)

Suggested Citation

V. Beral, C. Hermon, R. Peto, G. Reeves, L. Brinton, P. Marchbanks, E. Negri, R. B. Ness, P. H.M. Peeters, M. Vessey, E. E. Calle, S. M. Gapstur, A. V. Patel, L. Dal Maso, R. Talamini, A. Chetrit, G. Hirsh-Yechezkel, F. Lubin, S. Sadetzki, N. Allen, D. Bull, K. Callaghan, B. Crossley, K. Gaitskell, A. Goodill, J. Green, T. Key, K. Moser, R. Collins, R. Doll, C. A. Gonzalez, N. Lee, H. W. Ory, H. B. Peterson, P. A. Wingo, N. Martin, T. Pardthaisong, S. Silpisornkosol, C. Theetranont, B. Boosiri, S. Chutivongse, P. Jimakorn, P. Virutamasen, C. Wongsrichanalai, A. Tjonneland, L. Titus-Ernstoff, T. Byers, T. Rohan, B. J. Mosgaard, D. Yeates, J. L. Freudenheim, J. Chang-Claude, R. Kaaks, K. E. Anderson, A. Folsom, M. A. Rossing, D. B. Thomas, N. S. Weiss, E. Riboli, F. Clavel-Chapelon, D. Cramer, K. Robien, S. S. Tworoger, D. Cramer, S. E. Hankinson, S. S. Tworoger, S. Franceschi, C. La Vecchia, C. Magnusson, T. Riman, E. Weiderpass, A. Wolk, L. J. Schouten, P. A. Van den Brandt, N. Chantarakul, S. Koetsawang, D. Rachawat, D. Palli, A. Black, A. Berrington de Gonzalez, D. M. Freedman, P. Hartge, A. W. Hsing, J. V. Lacey, R. N. Hoover, C. Schairer, S. Graff-Iversen, R. Selmer, C. J. Bain, A. C. Green, D. M. Purdie, V. Siskind, P. M. Webb Ovarian cancer and body size: Individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Medicine. Vol.9, No.4 (2012). doi:10.1371/journal.pmed.1001200 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14892

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Title

Ovarian cancer and body size: Individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies

Author(s)

V. Beral
 C. Hermon
 R. Peto
 G. Reeves
 L. Brinton
 P. Marchbanks
 E. Negri
 R. B. Ness
 P. H.M. Peeters
 M. Vessey
 E. E. Calle
 S. M. Gapstur
 A. V. Patel
 L. Dal Maso
 R. Talamini
 A. Chetrit
 G. Hirsh-Yechezkel
 F. Lubin
 S. Sadetzki
 N. Allen
 D. Bull
 K. Callaghan
 B. Crossley
 K. Gaitskell
 A. Goodill
 J. Green
 T. Key
 K. Moser
 R. Collins
 R. Doll
 C. A. Gonzalez
 N. Lee
 H. W. Ory
 H. B. Peterson
 P. A. Wingo
 N. Martin
 T. Pardthaisong
 S. Silpisornkosol
 C. Theetranont
 B. Boosiri
 S. Chutivongse
 P. Jimakorn
 P. Virutamasen
 C. Wongsrichanalai
 A. Tjonneland
 L. Titus-Ernstoff
 T. Byers
 T. Rohan
 B. J. Mosgaard
 D. Yeates
 J. L. Freudenheim
 J. Chang-Claude
 R. Kaaks
 K. E. Anderson
 A. Folsom
 M. A. Rossing
 D. B. Thomas
 N. S. Weiss
 E. Riboli
 F. Clavel-Chapelon
 D. Cramer
 K. Robien
 S. S. Tworoger
 D. Cramer
 S. E. Hankinson
 S. S. Tworoger
 S. Franceschi
 C. La Vecchia
 C. Magnusson
 T. Riman
 E. Weiderpass
 A. Wolk
 L. J. Schouten
 P. A. Van den Brandt
 N. Chantarakul
 S. Koetsawang
 D. Rachawat
 D. Palli
 A. Black
 A. Berrington de Gonzalez
 D. M. Freedman
 P. Hartge
 A. W. Hsing
 J. V. Lacey
 R. N. Hoover
 C. Schairer
 S. Graff-Iversen
 R. Selmer
 C. J. Bain
 A. C. Green
 D. M. Purdie
 V. Siskind
 P. M. Webb

Other Contributor(s)

American Cancer Society
 IRCCS Centro Di Riferimento Oncologico Aviano
 The Gertner Institute
 Cancer Epidemiology Unit
 Clinical Trial Service Unit
 Institute Catala Oncologia
 Centers for Disease Control and Prevention
 Chiang Mai University
 Chulalongkorn University
 Institute of Cancer Epidemiology - Denmark
 Geisel School of Medicine at Dartmouth
 Colorado School of Public Health
 Albert Einstein College of Medicine of Yeshiva University
 Amtssygehuset i Herlev
 Department of Public Health
 University at Buffalo, State University of New York
 German Cancer Research Center
 University of Minnesota School of Public Health
 University of Washington, Seattle
 Imperial College London
 Centre de recherche en epidemiologie et sante des populations
 Harvard Medical School
 Brigham and Women's Hospital
 Channing Laboratory
 International Agency for Research on Cancer
 Universita degli Studi di Milano
 Karolinska Institutet
 Maastricht University
 Mahidol University
 Centro Per Lo Studio E La Prevenzione Oncologica
 National Cancer Institute
 Norwegian Institute of Public Health
 Queensland Institute of Medical Research
 Roswell Park Cancer Institute
 Royal College of General Practitioners' Oral Contraception Study
 Curtin University
 University of Texas System
 University of Massachusetts System
 Boston University
 Stanford University
 University of Athens Medical School
 Universidad de Chile
 University of Hawaii System
 Skånes universitetssjukhus
 University of Pennsylvania
 University Medical Center Utrecht
 University of Southern California
 University of Toronto
 Universitetet i Tromso
 George Washington University
 Vanderbilt University
 Organisation Mondiale de la Sante
 Yale University

Abstract

Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p < 0.001); this relationship did not vary significantly by women's age, year of birth, education, age at menarche, parity, menopausal status, smoking, alcohol consumption, having had a hysterectomy, having first degree relatives with ovarian or breast cancer, use of oral contraceptives, or use of menopausal hormone therapy. For body mass index, there was significant heterogeneity (p < 0.001) in the findings between ever-users and never-users of menopausal hormone therapy, but not by the 11 other factors listed above. The relative risk for ovarian cancer per 5 kg/m 2 increase in body mass index was 1.10 (95% CI, 1.07-1.13; p < 0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p = 0.02) in ever-users of hormone therapy. Conclusions: Ovarian cancer is associated with height and, among never-users of hormone therapy, with body mass index. In high-income countries, both height and body mass index have been increasing in birth cohorts now developing the disease. If all other relevant factors had remained constant, then these increases in height and weight would be associated with a 3% increase in ovarian cancer incidence per decade. © 2012 Collaborative Group on Epidemiological Studies of Ovarian Cancer.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/14892

Collections

Scopus 2011-2015