Publication: Release rate of indomethacin from coated granules
Issued Date
1988-01-01
Resource Type
ISSN
03639045
Other identifier(s)
2-s2.0-0023906605
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug Development and Industrial Pharmacy. Vol.14, No.5 (1988), 683-687
Suggested Citation
Narong Sarisuta, Jugpun Sirithunyalug Release rate of indomethacin from coated granules. Drug Development and Industrial Pharmacy. Vol.14, No.5 (1988), 683-687. doi:10.3109/03639048809151893 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15525
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Title
Release rate of indomethacin from coated granules
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Abstract
The purpose of this investigation was a study on sustained release coated granules manufactured by means of the air-suspension coating technique. The smoothed 12/20-mesh fractions of indomethacin granulation containing povidone as a binder were coated in a modified air-suspension coater with film of ethylcellulose-glyceryl monostea-rate mixture at various percents by weight of coat. The kinetics of drug release was determined and appears to conform to the first-order fashion. The relationship between the coating weight and the first-order release rate constant was developed and found to be in the form of exponential function. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.