Publication: Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
Issued Date
2021-05-01
Resource Type
ISSN
20013078
Other identifier(s)
2-s2.0-85106448800
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Extracellular Vesicles. Vol.10, No.7 (2021)
Suggested Citation
Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton, James W. Dear, Juan M. Falcón-Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge Mertens, Luca Musante, Eline Oeyen, Maija Puhka, Martin E. van Royen, Catherine Sánchez, Carolina Soekmadji, Visith Thongboonkerd, Volkert van Steijn, Gerald Verhaegh, Jason P. Webber, Kenneth Witwer, Peter S.T. Yuen, Lei Zheng, Alicia Llorente, Elena S. Martens-Uzunova Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. Journal of Extracellular Vesicles. Vol.10, No.7 (2021). doi:10.1002/jev2.12093 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76188
Research Projects
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Title
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
Author(s)
Uta Erdbrügger
Charles J. Blijdorp
Irene V. Bijnsdorp
Francesc E. Borràs
Dylan Burger
Benedetta Bussolati
James Brian Byrd
Aled Clayton
James W. Dear
Juan M. Falcón-Pérez
Cristina Grange
Andrew F. Hill
Harry Holthöfer
Ewout J. Hoorn
Guido Jenster
Connie R. Jimenez
Kerstin Junker
John Klein
Mark A. Knepper
Erik H. Koritzinsky
James M. Luther
Metka Lenassi
Janne Leivo
Inge Mertens
Luca Musante
Eline Oeyen
Maija Puhka
Martin E. van Royen
Catherine Sánchez
Carolina Soekmadji
Visith Thongboonkerd
Volkert van Steijn
Gerald Verhaegh
Jason P. Webber
Kenneth Witwer
Peter S.T. Yuen
Lei Zheng
Alicia Llorente
Elena S. Martens-Uzunova
Charles J. Blijdorp
Irene V. Bijnsdorp
Francesc E. Borràs
Dylan Burger
Benedetta Bussolati
James Brian Byrd
Aled Clayton
James W. Dear
Juan M. Falcón-Pérez
Cristina Grange
Andrew F. Hill
Harry Holthöfer
Ewout J. Hoorn
Guido Jenster
Connie R. Jimenez
Kerstin Junker
John Klein
Mark A. Knepper
Erik H. Koritzinsky
James M. Luther
Metka Lenassi
Janne Leivo
Inge Mertens
Luca Musante
Eline Oeyen
Maija Puhka
Martin E. van Royen
Catherine Sánchez
Carolina Soekmadji
Visith Thongboonkerd
Volkert van Steijn
Gerald Verhaegh
Jason P. Webber
Kenneth Witwer
Peter S.T. Yuen
Lei Zheng
Alicia Llorente
Elena S. Martens-Uzunova
Other Contributor(s)
Siriraj Hospital
Swansea University Medical School
Department of Chemical Engineering, TU Delft
Edinburgh Medical School
Erasmus MC Cancer Institute
CIC BioGUNE
Oslo Universitetssykehus
Cardiff University School of Medicine
OsloMet – storbyuniversitetet
University of Michigan Medical School
Erasmus MC
Vanderbilt University Medical Center
Università degli Studi di Torino, Scuola di Medicina
University of Virginia Health System
Hospital Universitari Germans Trias i Pujol
QIMR Berghofer Medical Research Institute
Universitätsklinikum des Saarlandes Medizinische Fakultät der Universität des Saarlandes
University of Louisville Health Sciences Center
Univerza v Ljubljani Medicinska Fakulteta
Clinica Las Condes
Universiteit Antwerpen
Università degli Studi di Torino
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
La Trobe University
Turun yliopisto
National Heart, Lung, and Blood Institute (NHLBI)
Universitätsklinikum Hamburg-Eppendorf
Helsingin Yliopisto
Southern Medical University
Radboud University Medical Center
Ottawa Hospital Research Institute
Amsterdam UMC - Free University Amsterdam
Johns Hopkins School of Medicine
Swansea University Medical School
Department of Chemical Engineering, TU Delft
Edinburgh Medical School
Erasmus MC Cancer Institute
CIC BioGUNE
Oslo Universitetssykehus
Cardiff University School of Medicine
OsloMet – storbyuniversitetet
University of Michigan Medical School
Erasmus MC
Vanderbilt University Medical Center
Università degli Studi di Torino, Scuola di Medicina
University of Virginia Health System
Hospital Universitari Germans Trias i Pujol
QIMR Berghofer Medical Research Institute
Universitätsklinikum des Saarlandes Medizinische Fakultät der Universität des Saarlandes
University of Louisville Health Sciences Center
Univerza v Ljubljani Medicinska Fakulteta
Clinica Las Condes
Universiteit Antwerpen
Università degli Studi di Torino
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
La Trobe University
Turun yliopisto
National Heart, Lung, and Blood Institute (NHLBI)
Universitätsklinikum Hamburg-Eppendorf
Helsingin Yliopisto
Southern Medical University
Radboud University Medical Center
Ottawa Hospital Research Institute
Amsterdam UMC - Free University Amsterdam
Johns Hopkins School of Medicine
Abstract
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field.