Publication: Changes in platelet count in uncomplicated and severe falciparum Malaria
Issued Date
2010-09-01
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ISSN
01251562
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2-s2.0-79952108713
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.41, No.5 (2010), 1035-1041
Suggested Citation
Wattana Leowattana, Noppadon Tangpukdee, Sai Kaung Thar, Souwanit Nakasiri, Siripun Srivilairit, Shigeyuki Kano, Polrat Wilairatana, Srivicha Krudsood Changes in platelet count in uncomplicated and severe falciparum Malaria. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.41, No.5 (2010), 1035-1041. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29549
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Title
Changes in platelet count in uncomplicated and severe falciparum Malaria
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Abstract
This study investigated alterations in platelet counts pre- and post-treatment with artemisinin derivatives in uncomplicated and severe falciparum malaria. Serial platelet counts were taken over 4 weeks for 110 uncomplicated and 110 severe falciparum malaria patients admitted to the Hospital for Tropical Diseases during 2005-2008. On admission, prior to treatment, thrombocytopenia was found in 73.6% of uncomplicated falciparum malaria patients and 90.9% of severe falciparum malaria cases. Platelet levels significantly lower in severe malaria cases. Although initial platelet counts were lower than normal in both study groups, they slowly increased significantly over time, and approached normal levels by several weeks post-treatment. No bleeding was evident during treatment, and none of the patients required a platelet transfusion. Platelet transfusions are not required for malaria patients with thrombocytopenia who have no bleeding.