Publication: Novel candidates for vaccine development against Mycoplasma capricolum subspecies capripneumoniae (Mccp)—Current knowledge and future prospects
Issued Date
2019-09-01
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ISSN
2076393X
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2-s2.0-85071367673
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Mahidol University
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SCOPUS
Bibliographic Citation
Vaccines. Vol.7, No.3 (2019)
Suggested Citation
Mohd Iqbal Yatoo, Oveas Raffiq Parray, Muheet, Riyaz Ahmed Bhat, Qurat Un Nazir, Abrar Ul Haq, Hamid Ullah Malik, Mujeeb Ur Rehman Fazilli, Arumugam Gopalakrishnan, Shah Tauseef Bashir, Ruchi Tiwari, Sandip Kumar Khurana, Wanpen Chaicumpa, Kuldeep Dhama Novel candidates for vaccine development against Mycoplasma capricolum subspecies capripneumoniae (Mccp)—Current knowledge and future prospects. Vaccines. Vol.7, No.3 (2019). doi:10.3390/vaccines7030071 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51026
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Title
Novel candidates for vaccine development against Mycoplasma capricolum subspecies capripneumoniae (Mccp)—Current knowledge and future prospects
Other Contributor(s)
ICAR - Central Institute for Research on Buffaloes, Hisar
SKUAST-Kashmir, Faculty of Veterinary Sciences and Animal Husbandry
Tamilnadu Veterinary Animal Sciences University
College of Veterinary Science India
Faculty of Medicine, Siriraj Hospital, Mahidol University
Indian Veterinary Research Institute
University of Illinois at Urbana-Champaign
SKUAST-Kashmir, Faculty of Veterinary Sciences and Animal Husbandry
Tamilnadu Veterinary Animal Sciences University
College of Veterinary Science India
Faculty of Medicine, Siriraj Hospital, Mahidol University
Indian Veterinary Research Institute
University of Illinois at Urbana-Champaign
Abstract
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Exploration of novel candidates for vaccine development against Mycoplasma capricolum subspecies capripneumoniae (Mccp), the causative agent of contagious caprine pleuropneumonia (CCPP), has recently gained immense importance due to both the increased number of outbreaks and the alarming risk of transboundary spread of disease. Treatment by antibiotics as the only therapeutic strategy is not a viable option due to pathogen persistence, economic issues, and concerns of antibiotic resistance. Therefore, prophylactics or vaccines are becoming important under the current scenario. For quite some time inactivated, killed, or attenuated vaccines proved to be beneficial and provided good immunity up to a year. However, their adverse effects and requirement for larger doses led to the need for production of large quantities of Mccp. This is challenging because the required culture medium is costly and Mycoplasma growth is fastidious and slow. Furthermore, quality control is always an issue with such vaccines. Currently, novel candidate antigens including capsular polysaccharides (CPS), proteins, enzymes, and genes are being evaluated for potential use as vaccines. These have shown potential immunogenicity with promising results in eliciting protective immune responses. Being easy to produce, specific, effective and free from side effects, these novel vaccine candidates can revolutionize vaccination against CCPP. Use of novel proteomic approaches, including sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), two-dimensional gel electrophoresis, immunoblotting, matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) mass spectrometry, tandem mass spectroscopy, fast protein liquid chromatography (FPLC), bioinformatics, computerized simulation and genomic approaches, including multilocus sequence analysis, next-generation sequencing, basic local alignment search tool (BLAST), gene expression, and recombinant expression, will further enable recognition of ideal antigenic proteins and virulence genes with vaccination potential.