Publication: A prospective, randomized trial of silver containing hydrofiber dressing versus 1% silver sulfadiazine for the treatment of partial thickness burns
Issued Date
2010-08-01
Resource Type
ISSN
1742481X
17424801
17424801
Other identifier(s)
2-s2.0-77954745062
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Wound Journal. Vol.7, No.4 (2010), 271-276
Suggested Citation
Pornprom Muangman, Chanin Pundee, Supaporn Opasanon, Saipin Muangman A prospective, randomized trial of silver containing hydrofiber dressing versus 1% silver sulfadiazine for the treatment of partial thickness burns. International Wound Journal. Vol.7, No.4 (2010), 271-276. doi:10.1111/j.1742-481X.2010.00690.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29568
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A prospective, randomized trial of silver containing hydrofiber dressing versus 1% silver sulfadiazine for the treatment of partial thickness burns
Other Contributor(s)
Abstract
Silver sulfadiazine has been used as a topical burn wound treatment for many years. Pain associated with dressing changes is a common problem in burn wounds. Aquacel Ag, a hydrofiber dressing coated with ionic silver has been reported to reduce burn wound infection and promote antimicrobial activity. The purpose of this study was to show the benefits of Aquacel Ag for the treatment of partial thickness burns. This prospective randomized study was conducted in 70 patients who had partial thickness burns less than 15% of total body surface area and were treated at Siriraj outpatient burn clinic during December 2006-February 2008. Patients were divided into two groups: Aquacel Ag-treated group with dressing changes every 3 days (35 patients) and 1% silver sulfadiazine-treated group, with daily dressing changes (35 patients). There was no difference in demographic data including age, gender, burn percentage between groups. Time-to-wound healing pain score during dressing change and cost of treatment were compared between both groups. Time-to-wound closure was significantly shorter in the Aquacel Ag-treated group (10 ± 3 versus 13.7 ± 4 days, P < 0·02) as well as pain scores at days 1, 3 and 7 (4·1 ± 2·1, 2·1 ± 1·8, 0·9 ± 1·4 versus 6·1 ± 2·3, 5·2 ± 2·1, 3·3 ± 1·9, respectively, P < 0·02). Total cost of treatment was 52 ± 29 US dollars for the Aquacel Ag-treated group versus 93 ± 36 US dollars for the silver sulfadiazine-treated group. This study showed that Aquacel Ag increased time to healing, decreased pain symptoms and increased patient convenience because of limiting the frequency of replacement of the dressing at lower total cost. This study confirms the efficacy of Aquacel Ag for the treatment of partial thickness burns at an outpatient clinic. © 2010 Blackwell Publishing Ltd and Medicalhelplines.com Inc.