Publication: Antioxidant Activity and Induction of mRNA Expressions of Antioxidant Enzymes in HEK-293 Cells of Moringa oleifera Leaf Extract
Issued Date
2015-07-10
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ISSN
14390221
00320943
00320943
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2-s2.0-84939616670
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.81, No.12-13 (2015), 1084-1089
Suggested Citation
Boonyadist Vongsak, Supachoke Mangmool, Wandee Gritsanapan Antioxidant Activity and Induction of mRNA Expressions of Antioxidant Enzymes in HEK-293 Cells of Moringa oleifera Leaf Extract. Planta Medica. Vol.81, No.12-13 (2015), 1084-1089. doi:10.1055/s-0035-1546168 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35425
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Title
Antioxidant Activity and Induction of mRNA Expressions of Antioxidant Enzymes in HEK-293 Cells of Moringa oleifera Leaf Extract
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Abstract
© Georg Thieme Verlag KG Stuttgart, New York. The leaves of Moringa oleifera, collected in different provinces in Thailand, were determined for the contents of total phenolics, total flavonoids, major components, and antioxidant activity. The extract and its major active components were investigated for the inhibition of H2O2-induced reactive oxygen species production and the effects on antioxidant enzymes mRNA expression. The extract, crypto-chlorogenic acid, isoquercetin and astragalin, significantly reduced the reactive oxygen species production inducing by H2O2 in HEK-293 cells. Treatment with isoquercetin significantly increased the mRNA expression levels of antioxidant enzymes such as superoxide dismutase, catalase and heme oxygenase 1. These results confirm that M. oleifera leaves are good sources of natural antioxidant with isoquercetin as an active compound.