Publication: Hb G Makassar (beta 6 : Glu→Ala) in a Thai Family
Issued Date
2002-05-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0036562796
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.85, No.5 (2002), 577-582
Suggested Citation
Siripakorn Sangkitporn, Budsaba Rerkamnuaychoke, Somchai Sangkitporn, Chartchai Mitrakul, Yavamal Sutivigit Hb G Makassar (beta 6 : Glu→Ala) in a Thai Family. Journal of the Medical Association of Thailand. Vol.85, No.5 (2002), 577-582. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20501
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Title
Hb G Makassar (beta 6 : Glu→Ala) in a Thai Family
Abstract
Hemoglobin G Makassar was identified in a family of Thai origin, which was found to share identical properties with hemoglobin S in routine hemoglobin separation both by cellulose acetate electrophoresis and cation-exchange HPLC. It is, therefore, subjects with hemoglobin G Makassar and hemoglobin S who may sometimes be mistakenly identified for each other. In this study, identification of hemoglobin G Makassar was achieved by DNA sequence analysis, which revealed a single nucleotide substitution GAG→GCG at codon 6 of the beta-globin gene. The hemoglobin variant was hemoglobin G Makassar [beta 6 : Glu→Ala]. This is the first report of hemoglobin G Makassar in Thailand.