Publication: Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis
Issued Date
2015-12-15
Resource Type
ISSN
15495477
08909369
08909369
Other identifier(s)
2-s2.0-84949986092
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Mahidol University
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SCOPUS
Bibliographic Citation
Genes and Development. Vol.29, No.24 (2015), 2603-2616
Suggested Citation
Zahra Kadri, Carine Lefevre, Olivier Goupille, Tipparat Penglong, Marine Granger-Locatelli, Suthat Fucharoen, Leila Maouche-Chretien, Philippe Leboulch, Stany Chretien Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis. Genes and Development. Vol.29, No.24 (2015), 2603-2616. doi:10.1101/gad.267633.115 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35321
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Title
Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis
Abstract
© 2015 Kadri et al. Tight coordination of cell proliferation and differentiation is central to red blood cell formation. Erythropoietin controls the proliferation and survival of red blood cell precursors, while variations in GATA-1/FOG-1 complex composition and concentrations drive theirmaturation. However, clear evidence of cross-talk between molecular pathways is lacking. Here, we show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1. In turn, FOG-1 displaces pRb/E2F-2 fromGATA-1, ultimately releasing free, proproliferative E2F-2. Mice bearing a Gata-1S310Amutation suffer fromfatal anemia when a compensatory pathway for E2F-2 production involving insulin-like growth factor-1 (IGF-1) signaling is simultaneously abolished. In the context of theGATA-1V205Gmutation resulting in lethal anemia, we show that the Ser310 cannot be phosphorylated and that constitutive phosphorylation at this position restores partial erythroid differentiation. This study sheds light on the GATA-1 pathways that synchronize cell proliferation and differentiation for tissue homeostasis.