Publication: The ongoing D-lemma of Vitamin D supplementation for nonskeletal health and bone health
Issued Date
2019-12-01
Resource Type
ISSN
17522978
1752296X
1752296X
Other identifier(s)
2-s2.0-85074553607
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Current Opinion in Endocrinology, Diabetes and Obesity. Vol.26, No.6 (2019), 301-305
Suggested Citation
Nipith Charoenngam, Arash Shirvani, Michael F. Holick The ongoing D-lemma of Vitamin D supplementation for nonskeletal health and bone health. Current Opinion in Endocrinology, Diabetes and Obesity. Vol.26, No.6 (2019), 301-305. doi:10.1097/MED.0000000000000508 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/50011
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The ongoing D-lemma of Vitamin D supplementation for nonskeletal health and bone health
Other Contributor(s)
Abstract
© 2019 Wolters Kluwer Health, Inc. All rights reserved. Purpose of reviewThe goal of this review is to give some perspective on the results and conclusions of three recent randomized controlled vitamin D intervention studies that have challenged the health benefit of vitamin D supplementation for reducing risk for cardiovascular disease, cancer, all-cause mortality and type 2 diabetes and improving bone health.Recent findingsVitamin D supplementation to adults who were vitamin D sufficient or insufficient did not reduce risk for developing cardiovascular disease, cancer, type 2 diabetes nor increases bone mineral density (BMD). Patients who were vitamin D deficient with cancer and received vitamin D reduced risk for mortality by 25% and prediabetic adults who were vitamin D deficient and received vitamin D reduced their risk of developing type 2 diabetes by 62%. Older adults receiving 4000 and 10000IUs of vitamin D3 daily for 3 years had reduced radial BMD but had no change in either total hip areal bone density or bone strength in the radius and tibia.SummaryCaution is needed when evaluating results and conclusions from randomized controlled trials that investigate health benefits of vitamin D; most studies suggest health benefits when vitamin D supplementation is provided to vitamin D deficient populations and little benefit when given to populations that are vitamin D sufficient/insufficient.
