Publication: Temporal change of SARS-CoV-2 in clinical specimens of COVID-19 pneumonia patients
Issued Date
2020-09-01
Resource Type
ISSN
14761645
00029637
00029637
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2-s2.0-85090271951
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.103, No.3 (2020), 1204-1206
Suggested Citation
Viravarn Luvira, Akanitt Jittmittraphap, Sant Muangnoicharoen, Nantarat Chantawat, Weena Janwitthayanan, Pornsawan Leaungwutiwong Temporal change of SARS-CoV-2 in clinical specimens of COVID-19 pneumonia patients. American Journal of Tropical Medicine and Hygiene. Vol.103, No.3 (2020), 1204-1206. doi:10.4269/ajtmh.20-0551 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59115
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Title
Temporal change of SARS-CoV-2 in clinical specimens of COVID-19 pneumonia patients
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Abstract
© 2020 by The American Society of Tropical Medicine and Hygiene The quality and type of specimen collection affect the sensitivity of real-time reverse transcriptase–PCR (rRT-PCR) for the diagnosis of SARS-CoV-2. In this report, the course over time of rRT-PCR for SARS-CoV-2 in 26 clinical specimens collected from the upper (nasopharyngeal and throat swabs) and lower (sputum) respiratory tracts of COVID-19 cases with pneumonia was investigated along with the clinical course. The preliminary results revealed that higher SARS-CoV-2 RNA concentration and longer time for detection make self-collected sputum a preferable specimen for the diagnosis and follow-up of COVID-19 pneumonia. Self-collection of sputum can minimize the risk of unnecessary exposure to healthcare workers, preserve the shortage of personal protective equipment, and limit viral transmission to the environment.