Publication: Alleviation of the Climacteric Symptoms with Oral Sequential Hormone Replacement Therapy
Issued Date
2004-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-1542348529
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.87, No.1 (2004), 1-7
Suggested Citation
Apichart Chittacharoen, Jittima Manonai, Siegfried Golbs, Reiner Domhardt, Urusa Theppisai Alleviation of the Climacteric Symptoms with Oral Sequential Hormone Replacement Therapy. Journal of the Medical Association of Thailand. Vol.87, No.1 (2004), 1-7. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21773
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Alleviation of the Climacteric Symptoms with Oral Sequential Hormone Replacement Therapy
Other Contributor(s)
Abstract
The efficacy of the oral hormone replacement therapy (HRT) preparation estradiol valerate/levonorgestrel (EV/LNG, Klimonorm®) in the alleviation of the menopausal complaints of peri- and postmenopausal Thai women was studied in a prospective, open, uncontrolled phase IV clinical trial. Of the 50 peri- or postmenopausal women screened, 39 completed the study. From them 31 were postmenopausal and 8 perimenopausal. The participants received EV/LNG over a period of 6 cycles. The Menopause Rating Scale II (MRS II) was used to assess the effect of EV/LNG on the menopausal symptoms. The changes in the main parameters of the MRS II during the treatment with EV/LNG showed that the general score decreased by 34.9 per cent after 3 months and was kept at the same value after 6 months of treatment. The somato-vegetative complaints decreassed by 32.5 per cent after 3 months and by 35 per cent after 6 months. The psychological complaints decreased by 34.1 per cent after 3 months and by 32.9 per cent after 6 months. The urogenital complaints decreased by 29.3 per cent after 3 months, and remained at the same level after 6 months of treatment. In conclusion, the 6-months administration of the oral HRT preparation estradiol valerate/levonorgestrel caused a considerable alleviation of the climacteric symptoms in menopausal women.