Publication: Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma
Issued Date
2018-01-01
Resource Type
ISSN
23146141
23146133
23146133
Other identifier(s)
2-s2.0-85044034915
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Mahidol University
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SCOPUS
Bibliographic Citation
BioMed Research International. Vol.2018, (2018)
Suggested Citation
Thitinee Vanichapol, Somchai Chutipongtanate, Usanarat Anurathapan, Suradej Hongeng Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma. BioMed Research International. Vol.2018, (2018). doi:10.1155/2018/1812535 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45305
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Title
Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma
Abstract
© 2018 Thitinee Vanichapol et al. Neuroblastoma (NB) is the most common extracranial solid tumor in childhood with 5-year survival rate of 40% in high-risk patients despite intensive therapies. Recently, adoptive cell therapy, particularly chimeric antigen receptor (CAR) T cell therapy, represents a revolutionary treatment for hematological malignancies. However, there are challenges for this therapeutic strategy with solid tumors, as a result of the immunosuppressive nature of the tumor microenvironment (TME). Cancer cells have evolved multiple mechanisms to escape immune recognition or to modulate immune cell function. Several subtypes of immune cells that infiltrate tumors can foster tumor development, harbor immunosuppressive activity, and decrease an efficacy of adoptive cell therapies. Therefore, an understanding of the dual role of the immune system under the influences of the TME has been crucial for the development of effective therapeutic strategies against solid cancers. This review aims to depict key immune players and cellular pathways involved in the dynamic interplay between the TME and the immune system and also to address challenges and prospective development of adoptive T cell transfer for neuroblastoma.