Publication:
Elevated urinary neopterin: A clue of activated macrophage and cellular immune response in the pathogenesis of idiopathic nephrotic syndrome

dc.contributor.authorVasant Sumethkulen_US
dc.contributor.authorGuy Neilden_US
dc.contributor.authorLakana Leohirunen_US
dc.contributor.authorPanas Chalermsanyakornen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUCL Medical School Institute of Urology and Nephrologyen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.date.accessioned2018-07-04T07:32:37Z
dc.date.available2018-07-04T07:32:37Z
dc.date.issued1996-01-01en_US
dc.description.abstractA study of cell mediated immunity (CMI) activation in patients with idiopathic nephrotic syndrome (INS) in the tropics was undertaken. Cell mediated immunity activation was investigated by measuring urinary neopterin excretion. All 31 patients with idiopathic nephrotic syndrome due to either minimal change nephrotic syndrome (MCNS), and focal and segmental glomerulosclerosis (FSGS) had significant elevation of neopterin excretion (mean values 451, 544 μmol neopterin/mol creatinine) when compared with 222 normal subjects (mean value 130, P<0.001). However, in 25 patients with non-nephrotic IgA nephropathy and eight nephrotic membranous nephropathy the urinary neopterin was not raised (mean value 131 and 129). A further 10 patients with MCNS were restudied when in complete remission and their urinary neopterin was found to have decreased significantly (mean value 186); however, this level was still above the normal range. Our study suggests that CMI and macrophage activation takes place in the pathogenesis of idiopathic nephrosis.en_US
dc.identifier.citationNephrology. Vol.2, No.2 (1996), 101-105en_US
dc.identifier.doi10.1111/j.1440-1797.1996.tb00072.xen_US
dc.identifier.issn13205358en_US
dc.identifier.other2-s2.0-1842485949en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/17816
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1842485949&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleElevated urinary neopterin: A clue of activated macrophage and cellular immune response in the pathogenesis of idiopathic nephrotic syndromeen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1842485949&origin=inwarden_US

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