Publication:
Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration

Issued Date

2018-04-01

Resource Type

Article

ISSN

19326203

DOI

10.1371/journal.pone.0191172

Other identifier(s)

2-s2.0-85045439183

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

PLoS ONE. Vol.13, No.4 (2018)

Suggested Citation

Matthias W. Lorenz, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R. Srinivasan, Lars Lind, Shuhei Okazaki, Coen D.A. Stehouwer, Peter Willeit, Joseph F. Polak, Helmuth Steinmetz, Dirk Sander, Holger Poppert, Moise Desvarieux, M. Arfan Ikram, Stein Harald Johnsen, Daniel Staub, Cesare R. Sirtori, Bernhard Iglseder, Oscar Beloqui, Gunnar Engström, Alfonso Friera, Francesco Rozza, Wuxiang Xie, Grace Parraga, Liliana Grigore, Matthieu Plichart, Stefan Blankenberg, Ta Chen Su, Caroline Schmidt, Tomi Pekka Tuomainen, Fabrizio Veglia, Henry Völzke, Giel Nijpels, Johann Willeit, Ralph L. Sacco, Oscar H. Franco, Heiko Uthoff, Bo Hedblad, Carmen Suarez, Raffaele Izzo, Dong Zhao, Thapat Wannarong, Alberico Catapano, Pierre Ducimetiere, Christine Espinola-Klein, Kuo Liong Chien, Jackie F. Price, Göran Bergström, Jussi Kauhanen, Elena Tremoli, Marcus Dörr, Gerald Berenson, Kazuo Kitagawa, Jacqueline M. Dekker, Stefan Kiechl, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Ellisiv B. Mathiesen, Samuela Castelnuovo, Manuel F. Landecho, Maria Rosvall, Rafael Gabriel, Nicola de Luca, Jing Liu, Damiano Baldassarre, Maryam Kavousi, Eric de Groot, Michiel L. Bots, David N. Yanez, Simon G. Thompson Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration. PLoS ONE. Vol.13, No.4 (2018). doi:10.1371/journal.pone.0191172 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/44792

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Title

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration

Author(s)

Matthias W. Lorenz
 Lu Gao
 Kathrin Ziegelbauer
 Giuseppe Danilo Norata
 Jean Philippe Empana
 Irene Schmidtmann
 Hung Ju Lin
 Stela McLachlan
 Lena Bokemark
 Kimmo Ronkainen
 Mauro Amato
 Ulf Schminke
 Sathanur R. Srinivasan
 Lars Lind
 Shuhei Okazaki
 Coen D.A. Stehouwer
 Peter Willeit
 Joseph F. Polak
 Helmuth Steinmetz
 Dirk Sander
 Holger Poppert
 Moise Desvarieux
 M. Arfan Ikram
 Stein Harald Johnsen
 Daniel Staub
 Cesare R. Sirtori
 Bernhard Iglseder
 Oscar Beloqui
 Gunnar Engström
 Alfonso Friera
 Francesco Rozza
 Wuxiang Xie
 Grace Parraga
 Liliana Grigore
 Matthieu Plichart
 Stefan Blankenberg
 Ta Chen Su
 Caroline Schmidt
 Tomi Pekka Tuomainen
 Fabrizio Veglia
 Henry Völzke
 Giel Nijpels
 Johann Willeit
 Ralph L. Sacco
 Oscar H. Franco
 Heiko Uthoff
 Bo Hedblad
 Carmen Suarez
 Raffaele Izzo
 Dong Zhao
 Thapat Wannarong
 Alberico Catapano
 Pierre Ducimetiere
 Christine Espinola-Klein
 Kuo Liong Chien
 Jackie F. Price
 Göran Bergström
 Jussi Kauhanen
 Elena Tremoli
 Marcus Dörr
 Gerald Berenson
 Kazuo Kitagawa
 Jacqueline M. Dekker
 Stefan Kiechl
 Matthias Sitzer
 Horst Bickel
 Tatjana Rundek
 Albert Hofman
 Ellisiv B. Mathiesen
 Samuela Castelnuovo
 Manuel F. Landecho
 Maria Rosvall
 Rafael Gabriel
 Nicola de Luca
 Jing Liu
 Damiano Baldassarre
 Maryam Kavousi
 Eric de Groot
 Michiel L. Bots
 David N. Yanez
 Simon G. Thompson

Other Contributor(s)

Deutsches Zentrum für Herz-Kreislauf-Forschung e. V.
 University Hospital of North Norway
 IRCCS Multimedica
 Itä-Suomen yliopisto
 IRCCS Centro Cardiologico Monzino
 Beijing Anzhen Hospital
 National Taiwan University Hospital
 Cardiovascular Research Institute Maastricht
 Sahlgrenska University Hospital, Wallenberg Laboratory
 University Medical Center Utrecht
 Erasmus University Medical Center
 Johannes Gutenberg Universität Mainz
 University of Cambridge
 Università degli Studi di Milano
 Robarts Research Institute
 Lunds Universitet
 Universite Paris Descartes
 Universitätsspital Basel
 Columbia University Medical Center
 University of Edinburgh
 Christian-Doppler-Klinik
 Tokyo Women's Medical University
 Klinikum Herford
 Hospital Universitario de la Princesa
 Universitätsklinikum Greifswald der Ernst-Moritz-Arndt-Universität Greifswald
 University of Miami Leonard M. Miller School of Medicine
 UiT The Arctic University of Norway
 Tulane University School of Public Health and Tropical Medicine
 Clinica Universitaria de Navarra
 Technical University of Munich
 Università degli Studi di Napoli Federico II
 Tufts University School of Medicine
 Ospedale Niguarda, Milan
 University of Washington, Seattle
 Tulane University School of Medicine
 Osaka University Faculty of Medicine
 EMGO Institute for Health and Care Research
 Groupe Hospitalier Broca AP-HP
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 University of Cambridge, Institute of Public Health
 Medizinische Universitat Innsbruck
 Goethe-Universität Frankfurt am Main
 National Taiwan University
 Universitätsklinikum Hamburg-Eppendorf und Medizinische Fakultät
 Uppsala Universitet
 Amsterdam UMC - Vrije Universiteit Amsterdam
 Instituto de Salud Carlos III
 Amsterdam UMC - University of Amsterdam
 University Paris_Sud Xi
 Benedictus Hospital Tutzing & Feldafing
 Parcelsus Medical University
 Imagelabonline & Cardiovascular
 SHIP/Clinical-Epidemiological Research
 University Medicine Greifswald
 Bassini Hospital
 Institut für Medizinische Biometrie

Abstract

© 2018 Lorenz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95–1.02) in group A, 0.98 (0.93–1.04) in group B, and 0.95 (0.89–1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07–1.23) in group A, 1.13 (1.05–1.22) in group B, and 1.12 (1.05–1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Keyword(s)

Agricultural and Biological Sciences
 Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/44792

Collections

Scopus 2018