Publication: A retrospective study of secondary bacteraemia in hospitalised adults with community acquired non-typhoidal Salmonella gastroenteritis
Issued Date
2013
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Language
eng
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Mahidol University
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BioMed Central
Bibliographic Citation
BMC Infectious Diseases. Vol.13, (2013), 107
Suggested Citation
Parry, Christopher M, Sherine Thomas, Aspinall, Esther J, Cooke, Richard PD, Rogerson, Stephen J, Harries, Anthony D, Beeching, Nicholas J A retrospective study of secondary bacteraemia in hospitalised adults with community acquired non-typhoidal Salmonella gastroenteritis. BMC Infectious Diseases. Vol.13, (2013), 107. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/3067
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Title
A retrospective study of secondary bacteraemia in hospitalised adults with community acquired non-typhoidal Salmonella gastroenteritis
Abstract
Background: The clinical significance of bacteraemia secondary to non-typhoidal Salmonella (NTS) gastroenteritis in
hospitalised adults is uncertain.
Methods: Adults admitted to a hospital in Liverpool, UK, with NTS gastroenteritis were identified using hospital
discharge data and laboratory records. Patients with known HIV infection were excluded. Risk factors for a
complicated or fatal course were determined.
Results: Between 1982 and 2006 inclusive, 633 adults were identified. Serovars causing infection included Enteritidis
(46.6%), Typhimurium (27.6%) and Virchow (4.9%). A blood culture was taken in 364 (57.5%) patients who were generally
sicker than those who were not cultured. Bacteraemia was detected in 63 (17.3%) patients who had blood cultures taken
(63/633 (10.0%) of all patients). Bacteraemia was more common in those aged ≥ 65 years (p < 0.001) and in those aged
< 65 years who had an underlying chronic disease. A complicated course occurred in 91 (25.0%) patients who had had a
blood culture taken (148/633 (23.4%) of all patients). Independent factors associated with a complicated or fatal course
among the patients investigated with a blood culture were bacteraemia (Adjusted Odds Ratio 5.34, 95% CI 2.86–9.95);
new onset confusion or coma (AOR 4.80, 95% CI 1.91–12.07); prolonged symptoms prior to admission (AOR 2.48, 95% CI
1.44–4.27); dehydration (AOR1.90, 95% CI 1.07–3.38); and absence of fever (AOR 0.56, 95% CI 0.32–0.95). The 30 day
attributable case fatality for all patients was 1.5%.
Conclusions: In this study secondary bacteraemia, as well as other clinical factors, was independently associated with a
complicated or fatal course in non-HIV infected adults admitted to hospital with NTS gastroenteritis.