Publication: Leptospirosis: Current situation and trends of specific laboratory tests
Issued Date
2013-03-11
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ISSN
17448409
1744666X
1744666X
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2-s2.0-84874630941
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Clinical Immunology. Vol.9, No.3 (2013), 263-280
Suggested Citation
Stefan Schreier, Galayanee Doungchawee, Sudarat Chadsuthi, Darapond Triampo, Wannapong Triampo Leptospirosis: Current situation and trends of specific laboratory tests. Expert Review of Clinical Immunology. Vol.9, No.3 (2013), 263-280. doi:10.1586/eci.12.110 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31949
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Leptospirosis: Current situation and trends of specific laboratory tests
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Abstract
Leptospirosis is re-emerging as a worldwide zoonosis and is caused by bacteria of the genus Leptospira. Human leptospirosis is associated with high temperature and humidity. Laboratory tests are indispensible for the early diagnosis and proper disease management. The demand for suitable leptospirosis point-of-care diagnostic tests grows with the awareness and number of incidences. Confirmation is achieved by the microscopic agglutination test, bacterial cultivation, PCR or histopathologic methods. However, high costs, poor standardization and/or elaborate sample preparation prevent routine use at the point of care. Cost-efficient, but insensitive serological methods dominate the diagnostic landscape and, likewise, urgently need improvement toward greater compliance with some of the point-of-care criteria. Combined application of antigen and antibody detection methods increases accuracy, but also new development or transfer of diagnostic technologies should be considered useful. Nano- and microparticle technology may play a key role in improving future antigen detection methods. © 2013 Expert Reviews Ltd.