Publication: Protective effects of diarylpropionitrile against hydrogen peroxide-induced damage in human neuroblastoma SH-SY5Y cells
Issued Date
2019-01-01
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ISSN
15256014
01480545
01480545
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2-s2.0-85072040450
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Mahidol University
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SCOPUS
Bibliographic Citation
Drug and Chemical Toxicology. (2019)
Suggested Citation
Nopparat Suthprasertporn, Nirut Suwanna, Wipawan Thangnipon Protective effects of diarylpropionitrile against hydrogen peroxide-induced damage in human neuroblastoma SH-SY5Y cells. Drug and Chemical Toxicology. (2019). doi:10.1080/01480545.2019.1658768 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50533
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Title
Protective effects of diarylpropionitrile against hydrogen peroxide-induced damage in human neuroblastoma SH-SY5Y cells
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Abstract
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Oxidative stress is implicated in pathogenesis of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. The study demonstrates diarylpropionitrile (DPN), an antioxidant selective agonist of estrogen receptor β, protected human neuroblastoma SH-SY5Y cells against H2O2-induced toxicity by attenuating production of reactive oxygen species, apoptosis, autophagy, NF-κB activation, MAPK p38, JNK and ERK 1/2 signaling pathways, and β-site amyloid precursor protein cleaving enzyme level, but, interestingly, stimulating Akt pathway. These findings indicate the important potential of DPN to ameliorate oxidative stress-associated damage in neurodegenerative disorders.