Publication: Human cerebral malaria in Thailand: A clinico-pathological correlation
Issued Date
1990-01-01
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ISSN
01652478
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2-s2.0-0025090886
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Mahidol University
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SCOPUS
Bibliographic Citation
Immunology Letters. Vol.25, No.1-3 (1990), 199-205
Suggested Citation
Mario Riganti, Emsri Pongponratn, Tatsuya Tegoshi, Sornchai Looareesuwan, Benjanee Punpoowong, Masamichi Aikawa Human cerebral malaria in Thailand: A clinico-pathological correlation. Immunology Letters. Vol.25, No.1-3 (1990), 199-205. doi:10.1016/0165-2478(90)90115-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15973
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Title
Human cerebral malaria in Thailand: A clinico-pathological correlation
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Abstract
Based on the cerebral malaria coma scale, 39 falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups of patients that had either cerebral malaria or non-cerebral malaria. We then studied significant pathological differences, such as parasitized erythrocyte (PRBC) sequestration, ring hemorrhages and cerebral edema, between these two groups in order to investigate the correlation between the clinical coma scale and pathological findings. Patients with a coma grade of 2 and higher were designated as having cerebral malaria, and had erythrocyte PRBC sequestration in cerebral microvessels. Ninety four percent (94%) of cerebral microvessels showed PRBC sequestration when quantitatively analyzed. On the other hand, only 13% of cerebral microvessels showed sequestration in non-cerebral malaria patients with a coma grade of 1 and lower, although some degree of PRBC sequestration was found in 50% of these patients. Our study, therefore, clearly demonstrated that the degree of the PRBC sequestration in cerebral microvessels appeared to correlate closely with the clinical coma scale. © 1990.