Publication: Transcytosis involvement in transport system and endothelial permeability of vascular leakage during dengue virus infection
Issued Date
2018-02-08
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ISSN
19994915
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2-s2.0-85041895723
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Mahidol University
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SCOPUS
Bibliographic Citation
Viruses. Vol.10, No.2 (2018)
Suggested Citation
Chanettee Chanthick, Aroonroong Suttitheptumrong, Nantapon Rawarak, Sa Nga Pattanakitsakul Transcytosis involvement in transport system and endothelial permeability of vascular leakage during dengue virus infection. Viruses. Vol.10, No.2 (2018). doi:10.3390/v10020069 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46046
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Title
Transcytosis involvement in transport system and endothelial permeability of vascular leakage during dengue virus infection
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Abstract
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage. Properly functioning endothelial cells promote physiological balance and stability for blood circulation and fluid components. A monolayer of endothelial cells has the ability to regulate paracellular and transcellular pathways for transport proteins, solutes, and fluid. In addition to the paracellular pathway, the transcellular pathway is another route of endothelial permeability that mediates vascular permeability under physiologic conditions. The transcellular pathway was found to be associated with an assortment of disease pathogeneses. The clinical manifestation of severe dengue infection in humans is vascular leakage and hemorrhagic diatheses. This review explores and describes the transcellular pathway, which is an alternate route of vascular permeability during dengue infection that corresponds with the pathologic finding of intact tight junction. This pathway may be the route of albumin transport that causes endothelial dysfunction during dengue virus infection.