Publication: Tamoxifen improved final height prediction in a girl with McCune-Albright Syndrome: Patient report and literature review
Issued Date
2006-01-01
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ISSN
0334018X
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2-s2.0-32944462009
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Pediatric Endocrinology and Metabolism. Vol.19, No.1 (2006), 81-86
Suggested Citation
Pairunyar Sawathiparnich, Prapanrat Osuwanaratana, Jeerunda Santiprabhob, Supawadee Likitmaskul Tamoxifen improved final height prediction in a girl with McCune-Albright Syndrome: Patient report and literature review. Journal of Pediatric Endocrinology and Metabolism. Vol.19, No.1 (2006), 81-86. doi:10.1515/JPEM.2006.19.1.81 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23101
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Title
Tamoxifen improved final height prediction in a girl with McCune-Albright Syndrome: Patient report and literature review
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Abstract
McCune-Albright syndrome (MAS) is characterized by gonadotropin-independent precocious puberty, café-au-lait spots on the skin and polyostotic fibrous dysplasia of bones. Treatment of precocious puberty (PP) in MAS should be considered in patients with poor predicted adult height (PAH). Treatment of gonadotropin-independent PP in MAS with ketoconazole, cyproterone acetate or testolactone, an aromatase inhibitor, does not appear to be always effective in slowing bone maturation. We report here a Thai girl with NUS who received tamoxifen, one of the selective estrogen receptor modulators, for the management of advanced puberty and rapid bone maturation. Her pubertal progression, vaginal bleeding, growth rate and PAH improved during treatment with tamoxifen despite persistently elevated serum estradiol levels and an enlarged ovarian cyst. © Freund Publishing House Ltd., London.