Publication: Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma
| dc.contributor.author | Sudarat Sombut | en_US |
| dc.contributor.author | Rada Bunthawong | en_US |
| dc.contributor.author | Uthaiwan Sirion | en_US |
| dc.contributor.author | Teerapich Kasemsuk | en_US |
| dc.contributor.author | Pawinee Piyachaturawat | en_US |
| dc.contributor.author | Kanoknetr Suksen | en_US |
| dc.contributor.author | Apichart Suksamrarn | en_US |
| dc.contributor.author | Rungnapha Saeeng | en_US |
| dc.contributor.other | Burapha University | en_US |
| dc.contributor.other | Rambhai Barni Rajabhat University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Ramkhamhaeng University | en_US |
| dc.date.accessioned | 2018-12-21T06:37:48Z | |
| dc.date.accessioned | 2019-03-14T08:02:37Z | |
| dc.date.available | 2018-12-21T06:37:48Z | |
| dc.date.available | 2019-03-14T08:02:37Z | |
| dc.date.issued | 2017-12-01 | en_US |
| dc.description.abstract | © 2017 Elsevier Ltd A series of 14-deoxy-11,12-didehydroandrographolide analogues were synthesized from naturally occurring andrographolide and their cytotoxicity evaluated against nine cancer cell lines including cholangiocarcinoma. Analogues 5a and 5b exhibited the most potent cytotoxicity with ED50s of 3.37 and 3.08 μM on KKU-M213 cell lines and 2.93 and 3.27 μM on KKU-100 cell lines, respectively. Selective cytotoxicity on cholangiocarcinoma cell lines identified in this study highlight the importance of structural modification in the development of drugs for this cancer. | en_US |
| dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters. Vol.27, No.23 (2017), 5139-5143 | en_US |
| dc.identifier.doi | 10.1016/j.bmcl.2017.10.063 | en_US |
| dc.identifier.issn | 14643405 | en_US |
| dc.identifier.issn | 0960894X | en_US |
| dc.identifier.other | 2-s2.0-85032748517 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/41648 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032748517&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032748517&origin=inward | en_US |