Publication: Acute changes in thyroid hormone levels among Thai pesticide sprayers
Issued Date
2021-01-01
Resource Type
ISSN
23056304
Other identifier(s)
2-s2.0-85099992670
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Mahidol University
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SCOPUS
Bibliographic Citation
Toxics. Vol.9, No.1 (2021), 1-16
Suggested Citation
Pornpimol Kongtip, Noppanun Nankongnab, Ritthirong Pundee, Nichcha Kallayanatham, Sumate Pengpumkiat, Jutamanee Chungcharoen, Chavisa Phommalachai, Pajaree Konthonbut, Nattagorn Choochouy, Preecha Sowanthip, Phanthawee Khangkhun, Jutharak Yimsabai, Susan Woskie Acute changes in thyroid hormone levels among Thai pesticide sprayers. Toxics. Vol.9, No.1 (2021), 1-16. doi:10.3390/toxics9010016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76564
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Title
Acute changes in thyroid hormone levels among Thai pesticide sprayers
Abstract
The objective of this study was to investigate the relationship of acute pesticide exposures and acute changes in thyroid hormones among Thai farmers. We recruited 78 farmers, who were scheduled to spray insecticides (chlorpyrifos and/or cypermethrin) or herbicides (paraquat and/or glyphosate). On the day before spraying, farmers collected their first morning void urine and went for blood collection. On the spray day, urine samples were collected at end of the spraying event and they were interviewed with questionnaires. The next morning, the first morning void urine and blood samples were collected. Blood samples were analyzed for thyroid hormones. Urine samples were analyzed for the metabolites of the pesticide sprayed. The results showed that the thyroid hormones, free triiodothyronine (FT3) and total triiodothyronine (T3) were significantly reduced as urinary chlorpyrifos metabolite increased the day after spraying. Total thyroxine (T4) significantly increased as cypermethrin metabolites increased the day after spraying. T4 significantly increased as urinary glyphosate levels increased; however, FT3 and T3 decreased significantly as urinary paraquat levels increased the day after spraying. These findings suggest that acute exposures to the pesticides chlorpyrifos, cypermethrin, paraquat and glyphosate can produce acute effects on the hypothalamic–pituitary–thyroid (HPT) axis, acutely altering thyroid hormone levels.