Publication: Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim
Issued Date
2021-01-01
Resource Type
ISSN
1759796X
20461402
20461402
Other identifier(s)
2-s2.0-85101966101
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
F1000Research. Vol.10, (2021)
Suggested Citation
Fabrizio Menardo, Sebastien Gagneux, Liliana K. Rutaihwa, Michaela Zwyer, Sonia Borrell, Iñaki Comas, Emilyn Costa Conceição, Mireia Coscolla, Helen Cox, Moses Joloba, Horng Yunn Dou, Julia Feldmann, Lukas Fenner, Janet Fyfe, Qian Gao, Darío García de Viedma, Alberto L. Garcia-Basteiro, Sebastian M. Gygli, Jerry Hella, Hellen Hiza, Levan Jugheli, Lujeko Kamwela, Midori Kato-Maeda, Qingyun Liu, Serej D. Ley, Chloe Loiseau, Surakameth Mahasirimongkol, Bijaya Malla, Prasit Palittapongarnpim, Niaina Rakotosamimanana, Voahangy Rasolofo, Miriam Reinhard, Klaus Reither, Mohamed Sasamalo, Rafael Silva Duarte, Christophe Sola, Philip Suffys, Karla Valeria Batista Lima, Dorothy Yeboah-Manu, Christian Beisel, Daniela Brites Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim. F1000Research. Vol.10, (2021). doi:10.12688/f1000research.28318.1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76403
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim
Author(s)
Fabrizio Menardo
Sebastien Gagneux
Liliana K. Rutaihwa
Michaela Zwyer
Sonia Borrell
Iñaki Comas
Emilyn Costa Conceição
Mireia Coscolla
Helen Cox
Moses Joloba
Horng Yunn Dou
Julia Feldmann
Lukas Fenner
Janet Fyfe
Qian Gao
Darío García de Viedma
Alberto L. Garcia-Basteiro
Sebastian M. Gygli
Jerry Hella
Hellen Hiza
Levan Jugheli
Lujeko Kamwela
Midori Kato-Maeda
Qingyun Liu
Serej D. Ley
Chloe Loiseau
Surakameth Mahasirimongkol
Bijaya Malla
Prasit Palittapongarnpim
Niaina Rakotosamimanana
Voahangy Rasolofo
Miriam Reinhard
Klaus Reither
Mohamed Sasamalo
Rafael Silva Duarte
Christophe Sola
Philip Suffys
Karla Valeria Batista Lima
Dorothy Yeboah-Manu
Christian Beisel
Daniela Brites
Sebastien Gagneux
Liliana K. Rutaihwa
Michaela Zwyer
Sonia Borrell
Iñaki Comas
Emilyn Costa Conceição
Mireia Coscolla
Helen Cox
Moses Joloba
Horng Yunn Dou
Julia Feldmann
Lukas Fenner
Janet Fyfe
Qian Gao
Darío García de Viedma
Alberto L. Garcia-Basteiro
Sebastian M. Gygli
Jerry Hella
Hellen Hiza
Levan Jugheli
Lujeko Kamwela
Midori Kato-Maeda
Qingyun Liu
Serej D. Ley
Chloe Loiseau
Surakameth Mahasirimongkol
Bijaya Malla
Prasit Palittapongarnpim
Niaina Rakotosamimanana
Voahangy Rasolofo
Miriam Reinhard
Klaus Reither
Mohamed Sasamalo
Rafael Silva Duarte
Christophe Sola
Philip Suffys
Karla Valeria Batista Lima
Dorothy Yeboah-Manu
Christian Beisel
Daniela Brites
Other Contributor(s)
Université Paris Cité
Instituto de Investigación Sanitaria Gregorio Marañón
Universite Paris-Saclay
Instituto de Salud Global de Barcelona
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Institut Pasteur de Madagascar
Papua New Guinea Institute of Medical Research
Makerere University
Ifakara Health Institute
CSIC - Instituto de Biomedicina de Valencia (IBV)
UCSF School of Medicine
Fundacao Oswaldo Cruz
ETH Zürich
Instituto Nacional de Infectologia Evandro Chagas (INI)
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
Universidade do Estado do Para
University of Bern
University of Ghana
Mahidol University
National Health Research Institutes Taiwan
Fudan University
Instituto Evandro Chagas
Thailand National Science and Technology Development Agency
Victorian Infectious Diseases Reference Laboratory
Universitat de València
University of Cape Town
Universidade Federal do Rio de Janeiro
Centro de Investigação em Saúde de Manhiça
Instituto de Investigación Sanitaria Gregorio Marañón
Universite Paris-Saclay
Instituto de Salud Global de Barcelona
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Institut Pasteur de Madagascar
Papua New Guinea Institute of Medical Research
Makerere University
Ifakara Health Institute
CSIC - Instituto de Biomedicina de Valencia (IBV)
UCSF School of Medicine
Fundacao Oswaldo Cruz
ETH Zürich
Instituto Nacional de Infectologia Evandro Chagas (INI)
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
Universidade do Estado do Para
University of Bern
University of Ghana
Mahidol University
National Health Research Institutes Taiwan
Fudan University
Instituto Evandro Chagas
Thailand National Science and Technology Development Agency
Victorian Infectious Diseases Reference Laboratory
Universitat de València
University of Cape Town
Universidade Federal do Rio de Janeiro
Centro de Investigação em Saúde de Manhiça
Abstract
Background: Lineage 1 (L1) and 3 (L3) are two lineages of the Mycobacterium tuberculosis complex (MTBC) causing tuberculosis (TB) in humans. L1 and L3 are prevalent around the rim of the Indian Ocean, the region that accounts for most of the world's new TB cases. Despite their relevance for this region, L1 and L3 remain understudied. Methods: We analyzed 2,938 L1 and 2,030 L3 whole genome sequences originating from 69 countries. We reconstructed the evolutionary history of these two lineages and identified genes under positive selection. Results: We found a strongly asymmetric pattern of migration from South Asia toward neighboring regions, highlighting the historical role of South Asia in the dispersion of L1 and L3. Moreover, we found that several genes were under positive selection, including genes involved in virulence and resistance to antibiotics For L1 we identified signatures of local adaptation at the esxH locus, a gene coding for a secreted effector that targets the human endosomal sorting complex, and is included in several vaccine candidates. Conclusions: Our study highlights the importance of genetic diversity in the MTBC, and sheds new light on two of the most important MTBC lineages affecting humans.