Publication: Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses
Issued Date
2011-07-26
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ISSN
17563305
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2-s2.0-79960560375
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasites and Vectors. Vol.4, No.1 (2011)
Suggested Citation
Sirilaksana Patramool, Pornapat Surasombatpattana, Natthanej Luplertlop, Martial Sévéno, Valérie Choumet, Frédéric Thomas, Dorothée Missé Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses. Parasites and Vectors. Vol.4, No.1 (2011). doi:10.1186/1756-3305-4-138 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12023
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Title
Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses
Abstract
Background: Proteomic analysis was performed to identify proteins regulated during infection by Dengue serotypes 1 and 3 in an Aedes albopictus cell line. The potential of these viruses to cause severe disease at primary infection is of interest although few studies have been performed with these two Dengue serotypes. Results: The most relevant observation of our study is the significant overexpression of proteins involved in the cellular stress response and the glycolysis pathway after 48 hours of infection. Viral infection activates the translation of some host genes, which may result in stress due to responses involving unfolded proteins. Conclusions: Therefore, the ox idation reduction and glycolytic mechanisms could participate in the antiviral response against Dengue virus. The results of our study should help to improve our knowledge of the virus-mosquito interaction at a cellular level with the aim of designing efficient strategies for the control of Dengue virus. © 2011 Patramool et al; licensee BioMed Central Ltd.