Publication: Lack of association between human immunodeficiency virus type 1 antibody in cervicovaginal lavage fluid and plasma and perinatal transmission, in Thailand
Issued Date
2000-07-10
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ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0034049841
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.181, No.6 (2000), 1957-1963
Suggested Citation
Rutt Chuachoowong, Nathan Shaffer, Thomas C. VanCott, Pongsakdi Chaisilwattana, Wimol Siriwasin, Naris Waranawat, Nirun Vanprapar, Nancy L. Young, Timothy D. Mastro, John S. Lambert, Merlin L. Robb Lack of association between human immunodeficiency virus type 1 antibody in cervicovaginal lavage fluid and plasma and perinatal transmission, in Thailand. Journal of Infectious Diseases. Vol.181, No.6 (2000), 1957-1963. doi:10.1086/315499 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25977
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Title
Lack of association between human immunodeficiency virus type 1 antibody in cervicovaginal lavage fluid and plasma and perinatal transmission, in Thailand
Abstract
To determine the association between human immunodeficiency virus type 1 (HIV) - specific antibody and RNA levels in cervicovaginal lavage (CVL) samples and plasma, zidovudine treatment, and perinatal transmission, HIV subtype E gp 160-specific IgG and IgA were serially measured in a subset of 74 HIV-infected women in a placebo-controlled trial of zidovudine, beginning at 36 weeks of gestation. HIV IgG was detected in 100% of plasma and 97% of CVL samples; HIV IgA was consistently detected in 62% of plasma and 31% of CVL samples. Antibody titers in CVL samples correlated better with the RNA level in CVL samples than with plasma antibody titers. Zidovudine did not affect antibody titers. Perinatal HIV transmission was not associated with antibody in CVL samples or plasma. HIV-specific antibody is present in the cervicovaginal canal of HIV-infected pregnant women; its correlation with the RNA level in CVL fluid suggests local antibody production. However, there was no evidence that these antibodies protected against perinatal HIV transmission.