Publication: Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728
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Issued Date
2020-01-01
Resource Type
ISSN
14786427
14786419
14786419
Other identifier(s)
2-s2.0-85078025640
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Research. (2020)
Suggested Citation
Siriporn Saepua, Jittra Kornsakulkarn, Patchanee Auncharoen, Pranee Rachtawee, Surisa Kongthong, Nattawut Boonyuen, David J. Harding, Tatsuo Nehira, Tienthong Thongpanchang, Chawanee Thongpanchang Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728. Natural Product Research. (2020). doi:10.1080/14786419.2020.1713119 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/53537
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Title
Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728
Abstract
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Five new compounds, iranginins A–E (1–5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher’s method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).