Publication: Angiotensin II receptor blocker partially ameliorated intrarenal hypoxia in chronic kidney disease patients: A pre-/post-study
Issued Date
2012-04-01
Resource Type
ISSN
14455994
14440903
14440903
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2-s2.0-84859856686
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Mahidol University
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SCOPUS
Bibliographic Citation
Internal Medicine Journal. Vol.42, No.4 (2012)
Suggested Citation
K. Manotham, B. Ongvilawan, P. Urusopone, S. Chetsurakarn, J. Tanamai, P. Limkuansuwan, K. Tungsanga, S. Eiam-Ong Angiotensin II receptor blocker partially ameliorated intrarenal hypoxia in chronic kidney disease patients: A pre-/post-study. Internal Medicine Journal. Vol.42, No.4 (2012). doi:10.1111/j.1445-5994.2011.02610.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14874
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Title
Angiotensin II receptor blocker partially ameliorated intrarenal hypoxia in chronic kidney disease patients: A pre-/post-study
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Abstract
Chronic intrarenal hypoxia has been regarded as a pathogenic factor of progressive renal damage. However, the lack of available human data has impeded the progress in this field. In this work, blood oxygen level-dependent magnetic resonance imaging was used to determine intrarenal oxygen status pre- and post-angiotensin receptor blockade (olmesartan) treatment in normal subjects, diabetic chronic kidney disease (CKD) patients and non-diabetic CKD patients. The mean R 2 *, which represents intrarenal oxygenation, was significantly lower in the control group than in the CKD group (12.42 ± 0.53/s vs 18.89 ± 3.15/s, P < 0.01), indicating the presence of intrarenal hypoxia in the CKD patients. The olmesartan treatment induced a 16.2 ± 7.7% decrement of the mean R 2 * in CKD patients, suggesting that this drug had an intrarenal hypoxia ameliorating effect. © 2012 The Authors. Internal Medicine Journal © 2012 Royal Australasian College of Physicians.