Publication: Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum
Issued Date
2007-11-01
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ISSN
00435325
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2-s2.0-36048942308
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Mahidol University
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SCOPUS
Bibliographic Citation
Wiener Klinische Wochenschrift. Vol.119, No.SUPPL. 3 (2007), 53-59
Suggested Citation
Maria Parizek, Jeeraphat Sirichaisinthop, Gunther Wernsdorfer, Harald Noedl, Herwig Kollaritsch, Walther H. Wernsdorfer Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum. Wiener Klinische Wochenschrift. Vol.119, No.SUPPL. 3 (2007), 53-59. doi:10.1007/s00508-007-0870-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24698
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Title
Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum
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Abstract
The blood schizontocidal activity of monodesbutyl-benflumetol (DBB), retinol (RET) and combinations (DBB-RET) at retinol concentrations corresponding to the 50th, 65thand 80thpercentile of physiological retinol concentrations in healthy adults has been investigated in Plasmodium falciparum. Parallel in vitro tests with DBB, RET and the 3 DBB-RET combinations were carried out with 26 fresh parasite isolates from northwestern Thailand, following the WHO standard protocol Mark II for determining the inhibition of schizont maturation. The EC50values for DBB, RET and for DBB in DBB-RET low, medium and high were 5.72 nM, 561.83 nM, 1.68 nM, 0.60 nM and 0.07 nM, respectively, the EC90values 44.14 nM, 9338.60 nM, 49.00 nM, 28.48 nM and 8.94 nM. The geometric mean cut-off concentrations of schizont maturation for DBB alone and for DBB in DBB-RET low, medium and high were 153.20 nM, 62.93nM, 34.00 nM and 13.74 nM, respectively, indicating significant synergistic interaction between DBB and retinol. The degree of synergism increases with the retinol concentration in the combination and is highest at the EC99level for DBB. © 2007 Springer-Verlag.