Publication: Influence of conjugating folic acid and methotrexate on physicochemical properties of P(CL)-mPEG nanoparticles
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2015-01-01
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2-s2.0-84983389473
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Mahidol University
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SCOPUS
Bibliographic Citation
NSTI: Advanced Materials - TechConnect Briefs 2015. Vol.3, (2015), 94-97
Suggested Citation
O. Issarachot, J. Suksiriworapong, K. Sripha, R. Yumoto, M. Takano, V. B. Junyaprasert Influence of conjugating folic acid and methotrexate on physicochemical properties of P(CL)-mPEG nanoparticles. NSTI: Advanced Materials - TechConnect Briefs 2015. Vol.3, (2015), 94-97. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35572
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Title
Influence of conjugating folic acid and methotrexate on physicochemical properties of P(CL)-mPEG nanoparticles
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Abstract
Copyright 2015 by TechConnect. All rights reserved. The objective of this study was to investigate an effect of conjugating folic acid (FOL) as a targeting ligand and conjugating methotrexate (MTX) as an anticancer drug on the formation of nanoparticles (NPs). MTX-conjugated nanoparticles were prepared using 10, 20 and 30 % MTX conjugated poly(e-caprolactone)-co-methoxy poly(ethylene glycol) (P(MTXCLCL)-mPEG) copolymers by dialysis method. Additionally, the targeted nanoparticles were obtained by the physical adsorption of FOL-conjugated (P(FOLCL)-mPEG) copolymer on the surface of P(MTXCLCL)-mPEG nanoparticles. The particle size of P(MTXCLCL)-mPEG nanoparticles increased with an amount of conjugating MTX. After the adsorption of P(FOLCL)-mPEG, the nanoparticles became larger and the zeta potential turned to more negative by approximately two times. All nanoparticles were spherical in shape and uniform size distribution. The % yield of nanoparticles ranged between 52-58%. The release profile showed higher release of MTX in acidic pH medium.