Publication: Asian Thoracic Oncology Research Group Expert Consensus Statement on Optimal Management of Stage III NSCLC
Issued Date
2020-03-01
Resource Type
ISSN
15561380
15560864
15560864
Other identifier(s)
2-s2.0-85080091130
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Thoracic Oncology. Vol.15, No.3 (2020), 324-343
Suggested Citation
Wan Ling Tan, Kevin L.M. Chua, Chia Chi Lin, Victor H.F. Lee, Lye Mun Tho, Anthony W. Chan, Gwo Fuang Ho, Thanyanan Reungwetwattana, James C. Yang, Dong Wan Kim, Ross A. Soo, Yong Chan Ahn, Hiroshi Onishi, Myung Ju Ahn, Tony S.K. Mok, Daniel S.W. Tan, Fan Yang Asian Thoracic Oncology Research Group Expert Consensus Statement on Optimal Management of Stage III NSCLC. Journal of Thoracic Oncology. Vol.15, No.3 (2020), 324-343. doi:10.1016/j.jtho.2019.10.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/53744
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Title
Asian Thoracic Oncology Research Group Expert Consensus Statement on Optimal Management of Stage III NSCLC
Other Contributor(s)
Peking University People's Hospital
National Taiwan University Hospital
National Cancer Centre, Singapore
National University Hospital, Singapore
Seoul National University Hospital
SungKyunKwan University, School of Medicine
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
University of Malaya Medical Centre
University of Yamanashi
The University of Hong Kong
Chinese University of Hong Kong
Beacon Hospital
National Taiwan University Hospital
National Cancer Centre, Singapore
National University Hospital, Singapore
Seoul National University Hospital
SungKyunKwan University, School of Medicine
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
University of Malaya Medical Centre
University of Yamanashi
The University of Hong Kong
Chinese University of Hong Kong
Beacon Hospital
Abstract
© 2019 Stage III NSCLC represents a heterogeneous disease for which optimal treatment continues to pose a clinical challenge. Recent changes in the American Joint Commission on Cancer staging to the eighth edition has led to a shift in TNM stage grouping and redefined the subcategories (IIIA–C) in stage III NSCLC for better prognostication. Although concurrent chemoradiotherapy has remained standard-of-care for stage III NSCLC for almost 2 decades, contemporary considerations include the impact of different molecular subsets of NSCLC, and the roles of tyrosine kinase inhibitors post-definitive therapy and of immune checkpoint inhibitors following chemoradiotherapy. With rapid evolution of diagnostic algorithms and expanding treatment options, the need for interdisciplinary input involving multiple specialists (medical oncologists, radiation oncologists, pulmonologists, radiologists, pathologists and thoracic surgeons) has become increasingly important. The unique demographics of Asian NSCLC pose further challenges when applying clinical trial data into clinical practice. This includes differences in smoking rates, prevalence of oncogenic driver mutations, and access to health care resources including molecular testing, prompting the need for critical review of existing data and identification of current gaps. In this expert consensus statement by the Asian Thoracic Oncology Research Group, an interdisciplinary group of experts representing Hong Kong, Korea, Japan, Taiwan, Singapore, Thailand, Malaysia, and Mainland China was convened. Standard clinical practices for stage III NSCLC across different Asian countries were discussed from initial diagnosis and staging through to multi-modality approaches including surgery, chemotherapy, radiation, targeted therapies, and immunotherapy.