Publication: Efficacy of chitin-PAA-GTMAC gel in promoting wound healing: Animal study
Issued Date
2011-11-01
Resource Type
ISSN
15734838
09574530
09574530
Other identifier(s)
2-s2.0-84355162227
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Materials Science: Materials in Medicine. Vol.22, No.11 (2011), 2497-2504
Suggested Citation
Kajee Pilakasiri, Patamaporn Molee, Duangkamol Sringernyuang, Noppadon Sangjun, Somruethai Channasanon, Siriporn Tanodekaew Efficacy of chitin-PAA-GTMAC gel in promoting wound healing: Animal study. Journal of Materials Science: Materials in Medicine. Vol.22, No.11 (2011), 2497-2504. doi:10.1007/s10856-011-4420-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11445
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Title
Efficacy of chitin-PAA-GTMAC gel in promoting wound healing: Animal study
Abstract
Acrylic grafted chitin (chitin-PAA) was modified with glycidyltrimethylammonium chloride (GTMAC) with the aim of promoting wound healing. The chitin-PAA-GTMAC gels with different GTMAC contents were compared with the original chitin-PAA gel and Intrasite gel for their efficacy in deep wound healing of Wistar rats. Four full-thickness wounds were made on the dorsal skin of rats and then each was treated with 4 materials; chitin-PAA, chitin-PAA-GTMAC(1:4), chitin-PAA-GTMAC(1:10) and Intrasite gel. During 18 days of treatment, the wounds were visually observed and calculated for wound size using image analysis program. Skin wound tissues of sacrificed rats were processed for routine histological observation and immunohistochemistry of proliferating cell nuclear antigen (PCNA). The wounds covered with the chitin derivatives either with or without GTMAC showed a significant reduction in wound size in day 9 in comparison with day 12 for those covered with Intrasite gel. The faster rate and the better pattern of epidermal development observed in histological study as well as the higher dermal cell proliferation (PCNA expression) also demonstrated the better efficiency in wound healing of the chitin derivatives than Intrasite. The earliest epidermal development of the wounds treated with chitin-PAA-GTMAC (1:4) among the tested materials suggested the most promising of this material for the treatment of full-thickness open wound. © 2011 Springer Science+Business Media, LLC.