Publication: Solid-supported acids as mild and versatile reagents for the deprotection of aromatic ethers
Issued Date
2007-07-05
Resource Type
ISSN
15237060
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2-s2.0-34547399577
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Mahidol University
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SCOPUS
Bibliographic Citation
Organic Letters. Vol.9, No.14 (2007), 2637-2640
Suggested Citation
Poonsakdi Ploypradith, Pannarin Cheryklin, Nattisa Niyomtham, Daniel R. Bertoni, Somsak Ruchirawat Solid-supported acids as mild and versatile reagents for the deprotection of aromatic ethers. Organic Letters. Vol.9, No.14 (2007), 2637-2640. doi:10.1021/ol070781+ Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24164
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Title
Solid-supported acids as mild and versatile reagents for the deprotection of aromatic ethers
Abstract
Equation Presented p-Toluene sulfonic acid (p-TsOH) immobilized either on polystyrene (PS) or silica (Si) was found to be effective in cleaving aromatic ethers containing isopropyl, tert-butyl, allyl, and benzyl groups, as well as mono-, di-, and trimethoxylated benzyl groups, in moderate to excellent yields (54-95%). These protecting groups could be selectively deprotected when they were simultaneously present on the same or different aromatic rings in a substrate. © 2007 American Chemical Society.