Publication: Urinary organophosphate metabolites and metabolic biomarkers of conventional and organic farmers in Thailand
Issued Date
2021-12-01
Resource Type
ISSN
23056304
Other identifier(s)
2-s2.0-85121718668
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Toxics. Vol.9, No.12 (2021)
Suggested Citation
Pornpimol Kongtip, Noppanun Nankongnab, Nichcha Kallayanatham, Jutamanee Chungcharoen, Chanapa Bumrungchai, Sumate Pengpumkiat, Susan Woskie Urinary organophosphate metabolites and metabolic biomarkers of conventional and organic farmers in Thailand. Toxics. Vol.9, No.12 (2021). doi:10.3390/toxics9120335 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76488
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Urinary organophosphate metabolites and metabolic biomarkers of conventional and organic farmers in Thailand
Other Contributor(s)
Abstract
Organophosphate (OP) pesticides are used by most farmers to remove insects and to increase productivity; however, questions remain on the long-term health impacts of their use. This study assessed the relationship between OP biomarker levels and metabolic biomarker parameters. Conventional farmers (n = 213) and organic farmers (n = 225) were recruited, interviewed, and had physical health examinations. Serum glucose and lipid profiles, triglycerides, total cholesterol, high-density lipoproteins (HDL), and low-density lipoproteins (LDL) were measured. The average age, gender, education, and self-reported agricultural work time, work in second jobs, smoking status, alcohol consumption, insecticide use at home, home location near farmlands and years of pesticide use were significantly different between the conventional and organic farmers. The urinary OP metabolite levels were also significantly different between the two groups. With an increase in urinary diethyl phosphate, dimethyl phosphate and dialkyl phosphate metabolites, the total cholesterol, LDL and HDL, were significantly increased for all farmers after controlling for age, gender, alcohol consumption, years of pesticide use, and home location near farmlands. The results are consistent with our previous studies which suggests that pesticide usage, especially organophosphates, may increase the risk of cardiovascular disease and stroke among Thai farmers.